1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

Base Information

Chemical Name:1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone
CAS No.:1374004-84-8
Molecular Formula:C₄₀H₃₅NO₆
Molecular Weight:625.721
Hs Code.:

Synonyms:1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

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Chemical Property of 1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

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Technology Process of 1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

There total 10 articles about 1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₂₆ClNO₆

: 1374004-84-8
1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: tri-n-butyl-tin hydride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

2: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

4: dihydrogen peroxide; potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C

With pyridine; dihydrogen peroxide; tri-n-butyl-tin hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 1374004-96-2
1-(5-benzyloxy-1H-indol-4-yl)-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

: 1374004-84-8
1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: tri-n-butyl-tin hydride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

4: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

5: dihydrogen peroxide; potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C

With pyridine; dihydrogen peroxide; tri-n-butyl-tin hydride; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 1374005-00-1
2-(5-benzyloxy-4-[2-(4-benzyloxy-3-methoxy-phenyl)-acetyl]-1H-indol-3-yl)-2-oxo-ethyl acetate

: 1374004-84-8
1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1-benzyl-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: dihydrogen peroxide; potassium carbonate / tetrahydrofuran; water / 2 h / 20 °C

With dihydrogen peroxide; potassium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.tet.2012.03.026