1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

Base Information

Chemical Name:1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone
CAS No.:1374004-99-5
Molecular Formula:C₃₃H₂₉NO₆
Molecular Weight:535.596
Hs Code.:

Synonyms:1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

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Chemical Property of 1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

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Technology Process of 1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

There total 8 articles about 1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₂₆ClNO₆

: 1374004-99-5
1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

Guidance literature:: With tri-n-butyl-tin hydride; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 1374004-96-2
1-(5-benzyloxy-1H-indol-4-yl)-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

: 1374004-99-5
1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

2: tri-n-butyl-tin hydride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With tri-n-butyl-tin hydride; In tetrahydrofuran;
DOI:10.1016/j.tet.2012.03.026

Reference yield:

: 1374004-91-7
2-(4-benzyloxy-3-methoxy-phenyl)-1-[5-benzyloxy-1-(toluene-4-sulfonyl)-1H-indol-4-yl]-ethanol

: 1374004-99-5
1-[5-benzyloxy-3-(2-hydroxy-acetyl)-1H-indol-4-yl]-2-(4-benzyloxy-3-methoxy-phenyl)-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / dimethyl sulfoxide / 2 h / 20 °C

2: methanol; potassium hydroxide / tetrahydrofuran / 0.5 h / Reflux

3: tetrahydrofuran / 1 h / 20 °C / Inert atmosphere

4: tri-n-butyl-tin hydride / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

With methanol; tri-n-butyl-tin hydride; potassium hydroxide; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/j.tet.2012.03.026