[⁽³⁾H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine

Base Information

• Chemical Name: [⁽³⁾H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine
• CAS No.: 1415914-08-7
• Molecular Formula: C₁₁H₁₂F₃N₃O
• Molecular Weight: 261.223

Synonyms:[⁽³⁾H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine

Chemical Property of [⁽³⁾H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of [⁽³⁾H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine

There total 8 articles about [⁽³⁾H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-4-(5-amino-2-fluoro-4-iodophenyl)-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-2-ylamine (1310350-58-3) → [(3)H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine (1415914-08-7)

Guidance literature:

With tritium; triethylamine; palladium-on-charcoal; In ethyl acetate; for 4h; under 532.553 Torr;

Reference yield:

1-(2-fluoro-5-nitrophenyl)ethanone (79110-05-7) → [(3)H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine (1415914-08-7)

Guidance literature:

Multi-step reaction with 8 steps

1: titanium(IV) oxide / tetrahydrofuran / Reflux

2: zinc / diethyl ether / 5 h / Inert atmosphere; Reflux

3: lithium borohydride / tetrahydrofuran / 0 - 20 °C

4: hydrogenchloride / 1,4-dioxane / 23 °C

5: ethanol / 23 °C / Inert atmosphere; Sealed tube

6: hydrogen / palladium-on-charcoal / ethanol / 1 h / 23 °C

7: dihydrogen peroxide; ammonium iodide / water; acetic acid / 20 °C

8: triethylamine; tritium / palladium-on-charcoal / ethyl acetate / 4 h / 532.55 Torr

With hydrogenchloride; ammonium iodide; lithium borohydride; tritium; hydrogen; dihydrogen peroxide; titanium(IV) oxide; triethylamine; zinc; palladium-on-charcoal; In tetrahydrofuran; 1,4-dioxane; diethyl ether; ethanol; water; acetic acid; ethyl acetate; 2: Reformatsky Reaction;

Reference yield:

(R)-3-amino-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)butan-1-ol (1075231-04-7) → [(3)H]-(R)-4-(5-amino-2-fluoro-phenyl)-5,5-difluoro-4-methyl-5 ,6-dihydro-4H-[1,3]oxazin-2-ylamine (1415914-08-7)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 23 °C / Inert atmosphere; Sealed tube

2: hydrogen / palladium-on-charcoal / ethanol / 1 h / 23 °C

3: dihydrogen peroxide; ammonium iodide / water; acetic acid / 20 °C

4: triethylamine; tritium / palladium-on-charcoal / ethyl acetate / 4 h / 532.55 Torr

With ammonium iodide; tritium; hydrogen; dihydrogen peroxide; triethylamine; palladium-on-charcoal; In ethanol; water; acetic acid; ethyl acetate;

upstream raw materials:

1-(2-fluoro-5-nitrophenyl)ethanone

(R)-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)-3-((R)-2-methylpropane-2-sulfinylamino)butyric acid ethyl ester

(R)-2-methylpropane-2-sulfinic acid [(R)-2,2-difluoro-1-(2-fluoro-5-nitrophenyl)-3-hydroxy-1-methylpropyl]amide

(R)-3-amino-2,2-difluoro-3-(2-fluoro-5-nitrophenyl)butan-1-ol

Downstream raw materials:

[⁽³⁾H]-5-but-2-ynyloxy-pyrazine-2-carboxylic acid [3-((R)-2-amino-5,5-difluoro-4-methyl-5,6-dihydro-4H-[1,3]oxazin-4-yl)-4-fluoro-phenyl]-amide

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