ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate

Base Information

• Chemical Name: ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate
• CAS No.: 150610-38-1
• Molecular Formula: C₁₉H₂₅NO₆
• Molecular Weight: 363.411

Synonyms:ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate

Chemical Property of ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate

There total 2 articles about ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.4%

4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester (70080-54-5) + (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (109431-87-0,83220-73-9) → ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate (150610-38-1)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 0.75h; Ambient temperature;

DOI:10.1021/jm00034a018

Reference yield:

4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester (70080-54-5) + (R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate (109431-87-0,83220-73-9) + diethylazodicarboxylate (1972-28-7,218603-74-8) → ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate (150610-38-1)

Guidance literature:

With triphenylphosphine; In tetrahydrofuran; chloroform; ethyl acetate; toluene;

Reference yield:

ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate (150610-38-1) → 2-[4-[[(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy]phenyl]-3-(7-cyano-2-naphthyl)propionic acid ethyl ester (204325-47-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / ethanol; tetrahydrofuran / 3 h / 20 °C

2: 6.24 g / H₂ / PdO*H₂O/BaSO₄ / tetrahydrofuran / 20 °C / 760 Torr

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium(II) oxide; barium sulfate; In tetrahydrofuran; ethanol; 1: Wittig reaction;

DOI:10.1016/j.bmc.2004.02.032

upstream raw materials:

4-hydroxy-alpha-oxobenzeneacetic acid ethyl ester

(R)-tert-butyl 3-hydroxypyrrolidine-1-carboxylate

diethylazodicarboxylate

Downstream raw materials:

(S)-3-{4-[(Z)-2-(5-Cyano-benzofuran-2-yl)-1-ethoxycarbonyl-vinyl]-phenoxy}-pyrrolidine-1-carboxylic acid tert-butyl ester

2-[4-[[(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl]oxy]phenyl]-3-(7-cyano-2-naphthyl)propionic acid ethyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 150610-38-1 ethyl 2-<4-<<(3S)-1-(tert-butoxycarbonyl)-3-pyrrolidinyl>oxy>phenyl>-2-oxoacetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send