8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol

Base Information

Chemical Name:8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol
CAS No.:202813-70-5
Molecular Formula:C₂₄H₄₀O₄Si
Molecular Weight:420.665
Hs Code.:

Synonyms:8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol

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Chemical Property of 8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol

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Technology Process of 8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol

There total 3 articles about 8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 73255-29-5
3-(hydroxymethyl)but-3-en-2-one

: 202813-70-5
8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 78 percent / CSA / CH₂Cl₂ / 3 h / 23 °C

2: 60 percent / NaHMDS / tetrahydrofuran / 1 h / -40 °C

3: 1.) Me₃SnSnMe₃, LiCl, 2.) n-BuLi / 1.) Pd(PPh₃)4 / 1.) THF, 60 deg C, 8 h, 2.) THF, -78 deg C, 20 min; -78 to 0 deg C, 1 h

With n-butyllithium; camphor-10-sulfonic acid; hexamethyldistannane; sodium hexamethyldisilazane; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane;
DOI:10.1002/anie.199728211

Reference yield:

: 202813-54-5
3-(((4-methoxybenzyl)oxy)methyl)but-3-en-2-one

: 202813-70-5
8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / NaHMDS / tetrahydrofuran / 1 h / -40 °C

2: 1.) Me₃SnSnMe₃, LiCl, 2.) n-BuLi / 1.) Pd(PPh₃)4 / 1.) THF, 60 deg C, 8 h, 2.) THF, -78 deg C, 20 min; -78 to 0 deg C, 1 h

With n-butyllithium; hexamethyldistannane; sodium hexamethyldisilazane; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran;
DOI:10.1002/anie.199728211

Reference yield:

: 87184-80-3
5-tert-butyldimethylsilyloxypentanal

: 202813-69-2
Trifluoro-methanesulfonic acid 2-(4-methoxy-benzyloxymethyl)-1-methylene-allyl ester

: 202813-70-5
8-(tert-Butyl-dimethyl-silanyloxy)-2-(4-methoxy-benzyloxymethyl)-3-methylene-oct-1-en-4-ol

Guidance literature:: With n-butyllithium; hexamethyldistannane; lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Yield given. Multistep reaction; 1.) THF, 60 deg C, 8 h, 2.) THF, -78 deg C, 20 min; -78 to 0 deg C, 1 h;
DOI:10.1002/anie.199728211