2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Base Information

Chemical Name:2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid
CAS No.:1509916-10-2
Molecular Formula:C₃₆H₄₉N₇O₉S
Molecular Weight:755.893
Hs Code.:

2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Synonyms:2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Chemical Property of 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

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Technology Process of 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

There total 10 articles about 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1509916-05-5
tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

: 1509916-10-2
2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 44.84 ℃;
DOI:10.1007/s00775-013-1055-8

Reference yield:

: 104-94-9
4-methoxy-aniline

: 1509916-10-2
2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / tetrahydrofuran / -0.16 °C

2: Lawessons reagent / chlorobenzene / Reflux

3: sodium hydroxide; potassium hexacyanoferrate(III) / Reflux

4: tin(ll) chloride / ethanol / Reflux

5: potassium carbonate / acetonitrile / 20 °C

6: potassium carbonate / acetonitrile / 48 h / 20 °C

7: trifluoroacetic acid / dichloromethane / 44.84 °C

With Lawessons reagent; potassium carbonate; triethylamine; trifluoroacetic acid; tin(ll) chloride; sodium hydroxide; potassium hexacyanoferrate(III); In tetrahydrofuran; ethanol; dichloromethane; chlorobenzene; acetonitrile;
DOI:10.1007/s00775-013-1055-8

Reference yield:

: 43036-14-2
6-methoxy-2-(4-nitrophenyl)benzothiazole

: 1509916-10-2
2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: tin(ll) chloride / ethanol / Reflux

2: potassium carbonate / acetonitrile / 20 °C

3: potassium carbonate / acetonitrile / 48 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 44.84 °C

With potassium carbonate; trifluoroacetic acid; tin(ll) chloride; In ethanol; dichloromethane; acetonitrile;
DOI:10.1007/s00775-013-1055-8