tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Base Information

• Chemical Name: tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate
• CAS No.: 1509916-05-5
• Molecular Formula: C₄₈H₇₃N₇O₉S
• Molecular Weight: 924.215
• Mol file: 1509916-05-5.mol

Synonyms:tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Chemical Property of tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate

There total 10 articles about tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

6-(2-chloroacetamido)-N-(4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)hexanamide (1509916-08-8) + 1,4,7-tris-tert-butoxycarbonylmethyl-1,4,7,10-tetraazacyclododecane (122555-91-3) → tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1509916-05-5)

Guidance literature:

With potassium carbonate; In acetonitrile; at 20 ℃; for 48h;

DOI:10.1007/s00775-013-1055-8

Reference yield:

4-methoxy-aniline (104-94-9) → tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1509916-05-5)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine / tetrahydrofuran / -0.16 °C

2: Lawessons reagent / chlorobenzene / Reflux

3: sodium hydroxide; potassium hexacyanoferrate(III) / Reflux

4: tin(ll) chloride / ethanol / Reflux

5: potassium carbonate / acetonitrile / 20 °C

6: potassium carbonate / acetonitrile / 48 h / 20 °C

With Lawessons reagent; potassium carbonate; triethylamine; tin(ll) chloride; sodium hydroxide; potassium hexacyanoferrate(III); In tetrahydrofuran; ethanol; chlorobenzene; acetonitrile;

DOI:10.1007/s00775-013-1055-8

Reference yield:

N-(4-methoxyphenyl)-4-nitrobenzamide (24730-11-8) → tri-tert-butyl 2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate (1509916-05-5)

Guidance literature:

Multi-step reaction with 5 steps

1: Lawessons reagent / chlorobenzene / Reflux

2: sodium hydroxide; potassium hexacyanoferrate(III) / Reflux

3: tin(ll) chloride / ethanol / Reflux

4: potassium carbonate / acetonitrile / 20 °C

5: potassium carbonate / acetonitrile / 48 h / 20 °C

With Lawessons reagent; potassium carbonate; tin(ll) chloride; sodium hydroxide; potassium hexacyanoferrate(III); In ethanol; chlorobenzene; acetonitrile;

DOI:10.1007/s00775-013-1055-8

upstream raw materials:

4-methoxy-aniline

N-(4-methoxyphenyl)-4-nitrobenzamide

N-(4-methoxyphenyl)-4-nitrothiobenzamide

6-methoxy-2-(4-nitrophenyl)benzothiazole

Downstream raw materials:

2,2',2''-(10-(2-((6-((4-(6-methoxybenzo[d]thiazol-2-yl)phenyl)amino)-6-oxohexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid