6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

Base Information

• Chemical Name: 6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol
• CAS No.: 1257557-42-8
• Molecular Formula: C₁₄H₁₅F₃N₄OS
• Molecular Weight: 344.361
• Mol file: 1257557-42-8.mol

Synonyms:6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

Chemical Property of 6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

There total 4 articles about 6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7,7-trifluoro-6-heptene-1,3-diol (1257557-41-7) + 1-Phenyl-1H-tetrazole-5-thiol (86-93-1) → 6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol (1257557-42-8)

Guidance literature:

6,7,7-trifluoro-6-heptene-1,3-diol; With tetrabutylammomium bromide; p-toluenesulfonyl chloride; sodium hydroxide; In toluene; for 0.5h; Cooling with ice;

1-Phenyl-1H-tetrazole-5-thiol; In toluene; at 60 ℃;

Reference yield:

ethyl 6,7,7-trifluoro-3-oxo-6-heptenoate (1257557-40-6) → 6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol (1257557-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium borohydride / tert-butyl methyl ether / 4 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: sodium hydroxide; p-toluenesulfonyl chloride; tetrabutylammomium bromide / toluene / 0.5 h / Cooling with ice

2.2: 60 °C

With lithium borohydride; tetrabutylammomium bromide; p-toluenesulfonyl chloride; sodium hydroxide; In tert-butyl methyl ether; toluene;

Reference yield:

4,5,5-trifluoropent-4-enoic acid (110003-22-0) → 6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol (1257557-42-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 20 °C / Cooling

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C

2.2: 0.5 h / -78 °C

3.1: lithium borohydride / tert-butyl methyl ether / 4 h / 20 °C / Cooling with ice

3.2: Cooling with ice

4.1: sodium hydroxide; p-toluenesulfonyl chloride; tetrabutylammomium bromide / toluene / 0.5 h / Cooling with ice

4.2: 60 °C

With lithium borohydride; tetrabutylammomium bromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; p-toluenesulfonyl chloride; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; tert-butyl methyl ether; toluene;

upstream raw materials:

4,5,5-trifluoropent-4-enoic acid

6,7,7-trifluoro-6-heptene-1,3-diol

1-Phenyl-1H-tetrazole-5-thiol

4,5,5-trifluoro-N-methoxy-N-methyl-4-penteneamide

Downstream raw materials:

6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-one

6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]-6-hepten-3-ol

1-phenyl-5-({6,7,7-trifluoro-3-methyl-3-[(trimethylsilyl)oxy]-6-hepten-1-yl}sulfonyl)-1H-tetrazole