6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

Base Information

• Chemical Name: 6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol
• CAS No.: 1257557-44-0
• Molecular Formula: C₁₅H₁₇F₃N₄OS
• Molecular Weight: 358.387
• Mol file: 1257557-44-0.mol

Synonyms:6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

Chemical Property of 6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

There total 6 articles about 6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-one (1257557-43-9) + methylmagnesium bromide (75-16-1) → 6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol (1257557-44-0)

Guidance literature:

6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-one; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at -78 ℃; for 1h; Cooling with ice;

With sodium hydrogencarbonate; In tetrahydrofuran; diethyl ether; water;

Reference yield:

6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol (1257557-42-8) → 6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol (1257557-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hypochlorite; potassium bromide / acetonitrile; water / 2 h / Cooling with ice

2: diethyl ether; tetrahydrofuran / 1 h / -78 °C / Cooling with ice

With sodium hypochlorite; potassium bromide; In tetrahydrofuran; diethyl ether; water; acetonitrile;

Reference yield:

ethyl 6,7,7-trifluoro-3-oxo-6-heptenoate (1257557-40-6) → 6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol (1257557-44-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: lithium borohydride / tert-butyl methyl ether / 4 h / 20 °C / Cooling with ice

1.2: Cooling with ice

2.1: sodium hydroxide; p-toluenesulfonyl chloride; tetrabutylammomium bromide / toluene / 0.5 h / Cooling with ice

2.2: 60 °C

3.1: sodium hypochlorite; potassium bromide / acetonitrile; water / 2 h / Cooling with ice

4.1: diethyl ether; tetrahydrofuran / 1 h / -78 °C / Cooling with ice

With sodium hypochlorite; lithium borohydride; tetrabutylammomium bromide; p-toluenesulfonyl chloride; potassium bromide; sodium hydroxide; In tetrahydrofuran; diethyl ether; tert-butyl methyl ether; water; toluene; acetonitrile;

upstream raw materials:

6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-ol

6,7,7-trifluoro-1-[(1-phenyl-1H-tetrazol-5-yl)thio]-6-hepten-3-one

methylmagnesium bromide

4,5,5-trifluoropent-4-enoic acid

Downstream raw materials:

6,7,7-trifluoro-3-methyl-1-[(1-phenyl-1H-tetrazol-5-yl)sulfonyl]-6-hepten-3-ol

1-phenyl-5-({6,7,7-trifluoro-3-methyl-3-[(trimethylsilyl)oxy]-6-hepten-1-yl}sulfonyl)-1H-tetrazole