(2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone

Base Information

• Chemical Name: (2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone
• CAS No.: 848033-75-0
• Molecular Formula: C₂₆H₃₃NO₃
• Molecular Weight: 407.553

Synonyms:(2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone

Chemical Property of (2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone

Chemical Property:

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Technology Process of (2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone

There total 2 articles about (2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

(1R,2S,5R)-5-methyl-2-<1-methyl-1-(benzylamino)ethyl>cyclohexan-1-ol (115156-56-4) + p-methoxyphenylglyoxal (1076-95-5) → (2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone (848033-75-0)

Guidance literature:

With water; In benzene; for 9h; Heating;

DOI:10.1021/jo052458v

Reference yield: 82.0%

2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one (16208-17-6) + (1R,2S,5R)-5-methyl-2-<1-methyl-1-(benzylamino)ethyl>cyclohexan-1-ol (115156-56-4) → (2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone (848033-75-0)

Guidance literature:

In benzene; for 9h; Heating;

DOI:10.1021/jo0481497

Reference yield: 58.0%

(2S,4aS,7R,8aR)-(3-benzyl-4,4,7-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2-yl)(4-methoxyphenyl)methanone (848033-75-0) → N-benzyl-N-[1-(2-hydroxy-4-methyl-cyclohexyl)-1-methyl-ethyl]-formamide + (1S,2S,2aS,3aR,5R,7aS)-2-(4-methoxyphenyl)-1-phenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol (848033-93-2)

Guidance literature:

In acetonitrile; at 25 ℃; for 5h; Irradiation;

DOI:10.1021/jo0481497

upstream raw materials:

2,2-dihydroxy-1-(4-methoxyphenyl)ethan-1-one

(1R,2S,5R)-5-methyl-2-<1-methyl-1-(benzylamino)ethyl>cyclohexan-1-ol

p-methoxyphenylglyoxal

Downstream raw materials:

(1S,2S,2aS,3aR,5R,7aS)-2-(4-methoxyphenyl)-1-phenyl-5,8,8-trimethyl-octahydro-1H,3aH-azeto[2,1-b][1,3]benzoxazin-2-ol

(1S,2S',4a'S,7'R,8a'R)-1-(3-benzyl-4',4',7'-trimethyloctahydro-2H-benzo[e][1,3]oxazin-2'-yl)-2,2,2-trifluoro-1-(4-methoxyphenyl)ethanol

(2S,5R)-2-{1-[(2S,3R)-3-Benzyloxy-3-(4-methoxy-phenyl)-2-phenyl-azetidin-1-yl]-1-methyl-ethyl}-5-methyl-cyclohexanone

(2S,3R)-N-(8-mentholyl)-3-benzyloxy-3-(4-methoxyphenyl)-2-phenyl-azetidine

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