(3-pyrimidin-2-ylphenyl)methanol

Base Information

• Chemical Name: (3-pyrimidin-2-ylphenyl)methanol
• CAS No.: 892502-12-4
• Molecular Formula: C11H10 N2 O
• Molecular Weight: 186.213
• Mol file: 892502-12-4.mol

Synonyms:(3-pyrimidin-2-ylphenyl)methanol

Chemical Property of (3-pyrimidin-2-ylphenyl)methanol

Chemical Property:

• Boiling Point: 283.0±32.0 °C(Predicted)
• PKA: 14.09±0.10(Predicted)
• PSA: 46.01000
• Density: 1.201±0.06 g/cm3(Predicted)
• LogP: 1.63590

Purity/Quality:

98%min ^*data from raw suppliers

(3-pyrimidin-2-ylphenyl)methanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3-pyrimidin-2-ylphenyl)methanol

There total 3 articles about (3-pyrimidin-2-ylphenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-(pyrimidin-2-yl)benzaldehyde (263349-22-0) → (3-(pyrimidin-2-yl)phenyl)methanol (892502-12-4)

Guidance literature:

With sodium tetrahydroborate; In methanol; at 20 ℃; for 12h;

DOI:10.1021/acs.joc.0c00007

Reference yield: 88.0%

2-bromopyrimidine (4595-60-2) + [3-(hydroxymethyl)phenyl]boronic acid (87199-15-3) → (3-(pyrimidin-2-yl)phenyl)methanol (892502-12-4)

Guidance literature:

With C₄₄H₃₂Cl₄I₂N₄P₂Pd₂; tetrabutylammomium bromide; caesium carbonate; In water; at 100 ℃; for 12h; Inert atmosphere;

DOI:10.1002/bkcs.10426

Reference yield:

2-phenylpyrimidine (7431-45-0) → (3-(pyrimidin-2-yl)phenyl)methanol (892502-12-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; N-Ac-Leu; [Ru(OAc)2(p-cymene)] / acetonitrile / 24 h / 120 °C / Sealed tube; Inert atmosphere

2: sodium tetrahydroborate / methanol / 12 h / 20 °C

With sodium tetrahydroborate; N-Ac-Leu; [Ru(OAc)2(p-cymene)]; potassium carbonate; In methanol; acetonitrile;

DOI:10.1021/acs.joc.0c00007

upstream raw materials:

2-bromopyrimidine

[3-(hydroxymethyl)phenyl]boronic acid

2-phenylpyrimidine

3-(pyrimidin-2-yl)benzaldehyde

Downstream raw materials:

2-(3-(bromomethyl)phenyl)pyrimidine

Refernces

• 1、 Gao, Hui,Xu, Chen,Li, Hong-Mei,Lou, Xin-Hua,Wang, Zhi-Qiang,Fu, Wei-Jun. "Dinuclear triphenylphosphine-cyclopalladated 2,4-dichloropyrimidine complex with a Pd-Pd bond: Synthesis, crystal structure, and application in Suzuki reaction of 3-(hydroxymethyl)phenylboronic acid in water". . p. 2355 - 2358. Retrieved 2015/09/15.