4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine

Base Information

• Chemical Name: 4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine
• CAS No.: 345912-64-3
• Molecular Formula: C₁₇H₁₀Cl₂N₄S
• Molecular Weight: 373.265

Synonyms:4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine

Chemical Property of 4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine

Chemical Property:

Purity/Quality:

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MSDS Files:

Useful:

Technology Process of 4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine

There total 4 articles about 4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carbonitrile (345912-36-9) → 4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine (345912-64-3)

Guidance literature:

With hydrogenchloride; acetic acid; sodium nitrite; In water; for 2h;

DOI:10.1080/10426500008076538

Reference yield:

(E)-2-(4-chlorobenzylidene)cyclopentan-1-one (134791-44-9) → 4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine (345912-64-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 65 percent / NaOMe / methanol / 48 h / 50 °C

2: 86 percent / AcONa*3H₂O / ethanol / 2 h / Heating

3: 90 percent / EtONa / ethanol / 0.08 h / Heating

4: 80 percent / NaNO₂; HCl; AcOH / H₂O / 2 h

With hydrogenchloride; sodium methylate; sodium ethanolate; sodium acetate; acetic acid; sodium nitrite; In methanol; ethanol; water; 3: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500008076538

Reference yield:

4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione (83236-50-4) → 4-chloro-10-(p-chlorophenyl)-cyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine (345912-64-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / AcONa*3H₂O / ethanol / 2 h / Heating

2: 90 percent / EtONa / ethanol / 0.08 h / Heating

3: 80 percent / NaNO₂; HCl; AcOH / H₂O / 2 h

With hydrogenchloride; sodium ethanolate; sodium acetate; acetic acid; sodium nitrite; In ethanol; water; 2: Thorpe-Ziegler cyclization;

DOI:10.1080/10426500008076538

upstream raw materials:

3-amino-4-(4-chloro-phenyl)-6,7-dihydro-5H-1-thia-8-aza-s-indacene-2-carbonitrile

(E)-2-(4-chlorobenzylidene)cyclopentan-1-one

4-<4-chlorophenyl>-3-cyano-5,6-trimethylenepyridine-2<1H>-thione

4-(4-chloro-phenyl)-2-cyanomethylsulfanyl-6,7-dihydro-5H-[1]pyrindine-3-carbonitrile

Downstream raw materials:

10-(p-chlorophenyl)-4-hydrazinocyclopenta[5',6']pyrido[3',2':4,5]thieno-[3,2-d]-[1,2,3]triazine

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