{6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone

Base Information

Chemical Name:{6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone
CAS No.:1159600-20-0
Molecular Formula:C₂₁H₂₀FN₃O₃S
Molecular Weight:413.473
Hs Code.:

Synonyms:{6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone

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Chemical Property of {6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone

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Technology Process of {6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone

There total 6 articles about {6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 123-90-0
Thiomorpholin

: 1159600-11-9
6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester

: 1159600-20-0
{6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone

Guidance literature:: Thiomorpholin; With trimethylaluminum; In 1,4-dioxane; toluene; at 20 ℃; for 1h;

6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester; In 1,4-dioxane; toluene; at 85 - 95 ℃; for 4h;

Reference yield:

: 1159251-38-3
[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol

: 1159600-20-0
{6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

2.1: trimethylaluminum / toluene; 1,4-dioxane / 1 h / 20 °C

2.2: 4 h / 85 - 95 °C

With trimethylaluminum; sodium hydride; In tetrahydrofuran; 1,4-dioxane; toluene; mineral oil;

Reference yield:

: 58606-42-1
N-hydroxy-3-fluoro-benzenecarboximidoyl chloride

: 1159600-20-0
{6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-thiomorpholin-4-yl-methanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / diethyl ether / 0 - 20 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 20 °C

3.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C

4.1: trimethylaluminum / toluene; 1,4-dioxane / 1 h / 20 °C

4.2: 4 h / 85 - 95 °C

With lithium aluminium tetrahydride; trimethylaluminum; sodium hydride; triethylamine; In tetrahydrofuran; 1,4-dioxane; diethyl ether; toluene; mineral oil;