3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile

Base Information

• Chemical Name: 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile
• CAS No.: 90475-83-5
• Molecular Formula: C₁₄H₁₃N₃O₂
• Molecular Weight: 255.276
• Mol file: 90475-83-5.mol

Synonyms:3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile

Chemical Property of 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile

There total 2 articles about 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

antipyrine (60-80-0) + acetic 2-cyanoacetic anhydride (64992-14-9) → 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile (90475-83-5)

Guidance literature:

With indium(III) chloride; In 1,4-dioxane; for 1h; Reflux;

DOI:10.3390/molecules17010897

Reference yield:

4-(chloroacetyl)antipyrine (6630-73-5) + sodium cyanide (143-33-9,25596-52-5) → 3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile (90475-83-5)

Guidance literature:

With ethanol; water;

Reference yield: 95.0%

3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxopropanenitrile (90475-83-5) + benzene diazonium chloride (100-34-5) → 3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxo-2-phenylazo-propionitrile (90475-90-4)

Guidance literature:

With sodium acetate; In ethanol;

DOI:10.1002/ardp.19843170402

upstream raw materials:

4-(chloroacetyl)antipyrine

sodium cyanide

antipyrine

acetic 2-cyanoacetic anhydride

Downstream raw materials:

2-(2-Chloro-phenylazo)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxo-propionitrile

3-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxo-2-phenylazo-propionitrile

2-(4-Chloro-phenylazo)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxo-propionitrile

2-(3,5-Bis-trifluoromethyl-phenylazo)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)-3-oxo-propionitrile