Antipyrine

Base Information Edit

Chemical Name:Antipyrine
CAS No.:60-80-0
Deprecated CAS:123175-91-7,5779-41-9
Molecular Formula:C11H12N2O
Molecular Weight:188.229
Hs Code.:29331190
European Community (EC) Number:200-486-6
ICSC Number:0376
NSC Number:755874,7945
UNII:T3CHA1B51H
DSSTox Substance ID:DTXSID6021117
Nikkaji Number:J2.340J
Wikipedia:Phenazone
Wikidata:Q415578
NCI Thesaurus Code:C76794
Pharos Ligand ID:7WY76MHB5MMB
Metabolomics Workbench ID:43561
ChEMBL ID:CHEMBL277474
Mol file:60-80-0.mol

Synonyms:Anodynin;Antipyrine;Phenazone;Pyramidone

Suppliers and Price of Antipyrine

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Antipyrine
10g
$ 875.00

TCI Chemical
2,3-Dimethyl-1-phenyl-5-pyrazolone >99.0%(GC)(T)
500g
$ 145.00

TCI Chemical
2,3-Dimethyl-1-phenyl-5-pyrazolone >99.0%(GC)(T)
25g
$ 21.00

Sigma-Aldrich
Antipyrine analytical standard
25g
$ 11.70

Sigma-Aldrich
Antipyrine analytical standard
100g
$ 34.90

Sigma-Aldrich
Antipyrine analytical reference material
100mg
$ 62.30

Sigma-Aldrich
Antipyrine tested according to Ph.Eur.
100g
$ 83.90

Sigma-Aldrich
Antipyrine analytical standard
500g
$ 105.00

Sigma-Aldrich
Phenazone European Pharmacopoeia (EP) Reference Standard
$ 190.00

Sigma-Aldrich
Phenazone European Pharmacopoeia (EP) Reference Standard
p0800000
$ 190.00

Total 202 raw suppliers

Chemical Property of Antipyrine Edit

Chemical Property:

Appearance/Colour:White Powder
Vapor Pressure:0.00522mmHg at 25°C
Melting Point:109-111 °C(lit.)
Refractive Index:1.553
Boiling Point:319 °C at 760 mmHg
PKA:pKa 1.4 (Uncertain)
Flash Point:114.8 °C
PSA：26.93000
Density:1.156 g/cm³
LogP:1.48440
Storage Temp.:Refrigerator
Solubility.:H2O: soluble1 gm in less than 1ml
Water Solubility.:1000 g/L (20 ºC)
XLogP3:0.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:188.094963011
Heavy Atom Count:14
Complexity:267

Purity/Quality:

99% ^*data from raw suppliers

Antipyrine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 22-36/37/38
Safety Statements: 26-36-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC1=CC(=O)N(N1C)C2=CC=CC=C2
Inhalation Risk:Evaporation at 20 °C is negligible; a harmful concentration of airborne particles can, however, be reached quickly when dispersed, especially if powdered.
Effects of Short Term Exposure:May cause mechanical irritation to the eyes and respiratory tract.
Effects of Long Term Exposure:The substance may have effects on the blood. This may result in anaemia.
Uses Antipyrine has been used for immunoblotting. It has also been used as an internal reference marker for studying the transport characteristics of platinum-containing drug, cisplatin in the human placenta in vitro. Antipyrine is an analgesic and antipyretic that has been given by mouth and as ear drops. It is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)

Technology Process of Antipyrine

There total 68 articles about Antipyrine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%