10.1002/kin.20745
The study investigates the charge-transfer (CT) complex formation between the donor antipyrine, a drug used as an analgesic and anti-inflammatory, and the acceptor 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ), a quinone with potential biological relevance. The research was conducted spectrophotometrically in various halocarbon and acetonitrile solvents to explore the molecular interaction, kinetics, and thermodynamics of the complex. The purpose of using these chemicals was to understand the formation of an electron donor-acceptor complex, assess the activation parameters such as activation energy, enthalpy, entropy, and free energy of activation, and determine the stoichiometry and formation constants of the resulting complexes. This information is crucial for understanding drug action, enzyme catalysis, and ion transfer in biological systems, as well as for developing analytical methods for drug detection and estimation.
10.1080/104265090969054
The study, titled "Versatile Synthesis of N,S-Heterocycles Containing the Antipyrine Moiety" focuses on synthesizing novel sulfur derivatives with potential biological activity, incorporating the antipyrine moiety. The primary chemicals involved include 4-(chloroacetyl)antipyrine (1) and 4-(cyanoacetyl)antipyrine (14), which serve as key starting materials. Compound 1 reacts with various sulfur nucleophiles, such as O-ethyl xanthic acid potassium salt, 4,5-dihydrothiazole-2-thiol, and pyrimidine-2-thiol, to produce corresponding sul?de derivatives (2–5). Additionally, compound 1 reacts with 2-aminobenzothiazole to form the imidazo[2,1-b]benzothiazole derivative (7). The 2-aminothiazole derivatives (10 and 11) are synthesized via a waste-free, solid-state reaction of compound 1 with thiourea derivatives (8 and 9). These aminothiazole products are then coupled with pyrazolopyridinyl and aromatic diazonium salts to create a series of azo dyes (12 and 13). Furthermore, compound 14 reacts with phenyl isothiocyanate to form a nonisolable adduct (15), which is used as a precursor for synthesizing ketene N,S-acetal (16), dihydrothiazole (17), and thiazolidinone (18) derivatives. The study explores the reactivity of these compounds and their potential applications in medicine and pharmacology, leveraging the known pharmacological properties of antipyrine derivatives.
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