Technology Process of tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate
There total 9 articles about tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-bromo-1-thiazol-2-yl-ethanone; tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate;
With
sodium hydrogencarbonate;
In
isopropyl alcohol;
at 72 - 92 ℃;
for 7h;
With
acetic acid;
at 60 ℃;
for 0.166667h;
With
ammonia; water;
In
methanol; dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 2327.23 Torr
2.1: sodium hydride / dimethyl sulfoxide / 1.5 h / 20 - 55 °C
3.1: sodium hydrogencarbonate / isopropyl alcohol / 7 h / 72 - 92 °C
3.2: 0.17 h / 60 °C
With
hydrogen; sodium hydride; sodium hydrogencarbonate;
palladium 10% on activated carbon;
In
methanol; dimethyl sulfoxide; isopropyl alcohol;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium phosphate / copper(l) iodide; trans-1,2-Diaminocyclohexane / 1,4-dioxane / 19 h / 120 °C
2.1: sodium hydride / dimethyl sulfoxide / 1.5 h / 20 - 55 °C
3.1: sodium hydrogencarbonate / isopropyl alcohol / 7 h / 72 - 92 °C
3.2: 0.17 h / 60 °C
With
potassium phosphate; sodium hydride; sodium hydrogencarbonate;
copper(l) iodide; trans-1,2-Diaminocyclohexane;
In
1,4-dioxane; dimethyl sulfoxide; isopropyl alcohol;
