tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate

Base Information

Chemical Name:tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate
CAS No.:1001014-22-7
Molecular Formula:C₃₂H₃₀N₆O₂S
Molecular Weight:562.695
Hs Code.:

Synonyms:tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate

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Chemical Property of tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate

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Technology Process of tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate

There total 9 articles about tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3292-77-1
2-bromo-1-thiazol-2-yl-ethanone

: 1001014-20-5
tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate

: 1001014-22-7
tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate

Guidance literature:: 2-bromo-1-thiazol-2-yl-ethanone; tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate; With sodium hydrogencarbonate; In isopropyl alcohol; at 72 - 92 ℃; for 7h;

With acetic acid; at 60 ℃; for 0.166667h;

With ammonia; water; In methanol; dichloromethane;

Reference yield:

: 689300-32-1
tert-butyl methyl(4-nitrobenzyl)carbamate

: 1001014-22-7
tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 2327.23 Torr

2.1: sodium hydride / dimethyl sulfoxide / 1.5 h / 20 - 55 °C

3.1: sodium hydrogencarbonate / isopropyl alcohol / 7 h / 72 - 92 °C

3.2: 0.17 h / 60 °C

With hydrogen; sodium hydride; sodium hydrogencarbonate; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 271-63-6
7-Azaindole

: 1001014-22-7
tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium phosphate / copper(l) iodide; trans-1,2-Diaminocyclohexane / 1,4-dioxane / 19 h / 120 °C

2.1: sodium hydride / dimethyl sulfoxide / 1.5 h / 20 - 55 °C

3.1: sodium hydrogencarbonate / isopropyl alcohol / 7 h / 72 - 92 °C

3.2: 0.17 h / 60 °C

With potassium phosphate; sodium hydride; sodium hydrogencarbonate; copper(l) iodide; trans-1,2-Diaminocyclohexane; In 1,4-dioxane; dimethyl sulfoxide; isopropyl alcohol;