tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate

Base Information

• Chemical Name: tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate
• CAS No.: 1001014-20-5
• Molecular Formula: C₂₇H₂₉N₅O₂
• Molecular Weight: 455.56
• Mol file: 1001014-20-5.mol

Synonyms:tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate

Chemical Property of tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate

There total 7 articles about tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 31.0%

(4-aminobenzyl)(methyl)carbamic acid tert-butyl ester (225240-83-5) + 4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzonitrile (1001013-59-7) → tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate (1001014-20-5)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 20 - 55 ℃; for 1.5h;

Reference yield:

tert-butyl methyl(4-nitrobenzyl)carbamate (689300-32-1) → tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate (1001014-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / methanol / 1 h / 20 °C / 2327.23 Torr

2: sodium hydride / dimethyl sulfoxide / 1.5 h / 20 - 55 °C

With hydrogen; sodium hydride; palladium 10% on activated carbon; In methanol; dimethyl sulfoxide;

Reference yield:

7-Azaindole (271-63-6) → tert-butyl 4-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamido)benzylmethylcarbamate (1001014-20-5)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium phosphate / copper(l) iodide; trans-1,2-Diaminocyclohexane / 1,4-dioxane / 19 h / 120 °C

2: sodium hydride / dimethyl sulfoxide / 1.5 h / 20 - 55 °C

With potassium phosphate; sodium hydride; copper(l) iodide; trans-1,2-Diaminocyclohexane; In 1,4-dioxane; dimethyl sulfoxide;

upstream raw materials:

(4-aminobenzyl)(methyl)carbamic acid tert-butyl ester

4-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzonitrile

tert-butyl methyl(4-nitrobenzyl)carbamate

7-Azaindole

Downstream raw materials:

tert-butyl 4-(2-(4-(1H-pyrrolo[2,3-b]pyridin-1-yl)phenyl)-4-(thiazol-2-yl)-1H-imidazol-1-yl)benzylmethylcarbamate