Technology Process of tert-Butyl 2-isothiocyanatobenzoate
There total 4 articles about tert-Butyl 2-isothiocyanatobenzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
thiophosgene;
With
triethylamine;
In
ethyl acetate;
at -78 ℃;
for 0.5h;
tert-butyl 2-aminobenzoate;
In
ethyl acetate;
at -78 - 20 ℃;
for 20.5h;
DOI:10.1021/jo4010876
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: palladium on activated charcoal; hydrogen / ethanol / 72 h / 1520.1 Torr
2.1: triethylamine / ethyl acetate / 0.5 h / -78 °C
2.2: 20.5 h / -78 - 20 °C
With
palladium on activated charcoal; hydrogen; triethylamine;
In
ethanol; ethyl acetate;
DOI:10.1021/jo4010876
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h
2.1: zinc(II) chloride / pyridine / 12 h
3.1: palladium on activated charcoal; hydrogen / ethanol / 72 h / 1520.1 Torr
4.1: triethylamine / ethyl acetate / 0.5 h / -78 °C
4.2: 20.5 h / -78 - 20 °C
With
oxalyl dichloride; palladium on activated charcoal; hydrogen; triethylamine; N,N-dimethyl-formamide; zinc(II) chloride;
In
pyridine; ethanol; dichloromethane; ethyl acetate;
DOI:10.1021/jo4010876