55666-41-6

Basic information

• Product Name: 2-NITRO-BENZOIC ACID TERT-BUTYL ESTER
• Synonyms: TERT-BUTYL 2-NITROBENZOATE;2-NITRO-BENZOIC ACID TERT-BUTYL ESTER
• CAS NO: 55666-41-6
• Molecular Formula: C₁₁H₁₃NO₄
• Molecular Weight: 223.23
• Mol File: 55666-41-6.mol
• Article Data: 17

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-NITRO-BENZOIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-NITRO-BENZOIC ACID TERT-BUTYL ESTER(55666-41-6)
• EPA Substance Registry System: 2-NITRO-BENZOIC ACID TERT-BUTYL ESTER(55666-41-6)

Safety Data

• Hazardous Substances Data: 55666-41-6(Hazardous Substances Data)

Usage

General Description

2-NITRO-BENZOIC ACID TERT-BUTYL ESTER, also known as 2-nitro-tert-butyl benzoate, is a chemical compound with the molecular formula C12H13NO4. It is a pale yellow solid with a sweet, floral odor, and is commonly used in the production of pharmaceuticals and fragrances. 2-NITRO-BENZOIC ACID TERT-BUTYL ESTER is created through the esterification of 2-nitrobenzoic acid with tert-butanol, and it is known for its high solubility in organic solvents such as ethanol and acetone. 2-NITRO-BENZOIC ACID TERT-BUTYL ESTER is also known for its potential hazards, including being harmful if swallowed, causing skin and eye irritation, and posing a risk to aquatic life.

Upstream product

• 610-14-0 2-nitrobenzyl chloride 
• 75-65-0 tert-butyl alcohol 
• 552-16-9 ortho-nitrobenzoic acid 
• 865-47-4 potassium tert-butylate 
• 201230-82-2 carbon monoxide 
• 577-19-5 2-nitrophenyl bromide 
• 606-27-9 methyl 2-nitrobenzoate 
• 115-11-7 isobutene 

Downstream Products

• 1364369-18-5 4-(2-(2-(tert-butoxycarbonyl)phenylazo)-5-hydroxyphenoxy)butanoic acid 
• 1364369-21-0 tert-butyl 2-(2-(4-(3-(7-(diethylamino)-2-oxo-2H-chromene-3-carboxamido)propylamino)-4-oxobutoxy)-4-hydroxyphenylazo)benzoate 
• 1364369-10-7 2-((2-(4-(3-(7-(diethylamino)-2-oxo-2H-chromene-3-carboxamido)propylamino)-4-oxobutoxy)-4-hydroxyphenyl)diazenyl)benzoic acid 
• 1364369-32-3 C₅₄H₇₈N₆O₁₆ 
• 1364369-34-5 C₅₁H₇₄N₆O₁₆ 
• 890091-28-8 tert-butyl 2-isothiocyanatobenzoate 
• 1452776-80-5 tert-butyl 2-(3-(4-methylbenzenesulfonyl)thioureido)benzoate 
• 1452849-69-2 (Z)-tert-butyl 2-((4-methylbenzenesulfonamido)(methylsulfanyl)-methyleneamino)benzoate 
• 1452849-70-5 (Z)-2-((4-methylbenzenesulfonamido)(methylsulfanyl)-methyleneamino)benzoic acid 
• 1452776-81-6 3-(4-methylbenzenesulfonyl)-2-(methylsulfanyl)quinazolin-4(3H)-one 
• 1070978-96-9 2,2'-ureylene-di-(tert-butylbenzoate) 
• 1070978-02-7 N-(3-(2-(pyrrolidin-1-yl)acetamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 1070977-96-6 N-(4-(2-(pyrrolidin-1-yl)acetamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 
• 1070977-98-8 N-(4-(3-(pyrrolidin-1-yl)propanamido)phenyl)-2-(1,2-dihydro-2,4-dioxoquinazolin-3(4H)-yl)benzamide 

Relevant articles and documents

TELOMERASE REVERSE TRANSCRIPTASE DEGRADERS AND METHODS OF USE THEREOF

The present disclosure provides TERT inhibitor compounds, a TERT inhibitor linked to a ubiquitin ligase ligand, as well as pharmaceutical compositions thereof. The present disclosure also provides methods of inhibiting telomerase reverse transcriptase (TERT) and methods of treating or preventing a disease or disorder using said compounds and/or compositions.

A FRET-based probe with a chemically deactivatable quencher

A new concept of a chemically deactivatable quencher is proposed for a FRET-based probe that turns-on its fluorescence by either an enzymatic cleavage or a chemical reagent (sodium dithionite). This concept allowed us to quantify the caspase-3 cleavage activity in solution and to reveal unreacted probes in cell experiments. The Royal Society of Chemistry 2012.

Efficient palladium-catalysed carbonylative and Suzuki-Miyaura cross-coupling reactions with bis(di-tert-butylphosphino)-o-xylene

The use of the ligand bis(di-tert-butylphosphino)-o-xylene (dtbpx) in palladium-catalysed carbonylative and Suzuki-Miyaura cross-coupling reactions is described. Aryl and vinyl halides readily entered into the carbonylative catalytic cycle affording carboxylic acids, amides as well as primary, secondary and tertiary esters, respectively, in good yields. Aryl iodides, bromides and chlorides gave high yields of biphenyl products upon reaction with both activated and unactivated boronic acids.