3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide

Base Information

Chemical Name:3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide
CAS No.:1415999-55-1
Molecular Formula:C₃₃H₃₅Cl₂F₂N₃O₉S
Molecular Weight:758.624
Hs Code.:

3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide

Synonyms:3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide

Suppliers and Price of 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide

There total 3 articles about 3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.2%

: C₃₁H₃₀Cl₂F₂N₂O₁₀S

: 124-40-3
dimethyl amine

: 1415999-55-1
3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide

Guidance literature:: With 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 48h;
DOI:10.1021/acs.jmedchem.7b01044

Reference yield:

: 51904-91-7
5-chlorosulfonyl-2-anisic acid

: 1416015-11-6
3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-((S)-pyrrolidine-2-carbonyloxy)ethyl)-pyridine 1-oxide

: 1415999-55-1
3,5-dichloro-4-((S)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-2-(((S)-1-((3-(dimethylcarbamoyl)-4-methoxyphenyl)sulfonyl)pyrrolidine-2-carbonyl)oxy)ethyl)-pyridine 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 4 h / 20 °C

2: 1,1'-carbonyldiimidazole / dichloromethane; tetrahydrofuran; N,N-dimethyl-formamide / 48 h / 20 °C

With pyridine; 1,1'-carbonyldiimidazole; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/acs.jmedchem.7b01044