1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS No.:224184-25-2
Molecular Formula:C₂₈H₂₁N₃O₃
Molecular Weight:447.493
Hs Code.:

Synonyms:1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

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Chemical Property of 1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

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Technology Process of 1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

There total 3 articles about 1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 905718-45-8
[(4-nitrophenyl)(phenyl)iodonium trifluoromethanesulfonate]

: 27441-93-6
3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

: 224184-25-2
1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: With ammonium hydroxide; In 1,2-dichloro-ethane; at 20 ℃; for 0.5h; Inert atmosphere;
DOI:10.1055/s-0036-1590920

Reference yield:

: 636-98-6
p-nitrobenzene iodide

: 27441-93-6
3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

: 224184-25-2
1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: With sodium acetate; copper; In N,N-dimethyl-formamide; at 150 ℃; for 4h;
DOI:10.1016/S0960-894X(99)00015-3

Reference yield:

: [1-(2-benzoyl-phenylcarbamoyl)-2-phenyl-ethyl]-carbamic acid tert-butyl ester

: 224184-25-2
1-(4-nitrophenyl)-3-benzyl-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: HCl (g) / ethyl acetate / 0 °C

2: MeOH, 1M NaOH

3: Cu powder, NaOAc / dimethylformamide / 4 h / 150 °C

With hydrogenchloride; methanol; sodium hydroxide; sodium acetate; copper; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0960-894X(99)00015-3