1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol

Base Information

• Chemical Name: 1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol
• CAS No.: 851779-77-6
• Molecular Formula: C₃₆H₅₃O₆P
• Molecular Weight: 612.787
• Mol file: 851779-77-6.mol

Synonyms:1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol

Chemical Property of 1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol

There total 6 articles about 1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

(1'R,4'S)-4-[4'-(4,4-dimethoxy-1-methylidenebutyl)-2',2'-dimethylcyclobutyl]butan-2-one (101927-11-1) + 1-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-propane (87109-17-9) → 1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol (851779-77-6)

Guidance literature:

1-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-propane; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃;

(1'R,4'S)-4-[4'-(4,4-dimethoxy-1-methylidenebutyl)-2',2'-dimethylcyclobutyl]butan-2-one; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1016/j.tet.2005.02.018

Reference yield:

5-iodo-2-pentanone (3695-29-2) → 1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol (851779-77-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: p-toluenesulfonic acid

2.1: NaOH

3.1: n-BuLi / tetrahydrofuran / -78 - 0 °C

3.2: 41 percent / tetrahydrofuran / -78 - 20 °C

With sodium hydroxide; n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; 4.2: Warren modification of Wittig reaction;

DOI:10.1016/j.tet.2005.02.018

Reference yield:

(3-(2-methyl-1,3-dioxolan-2-yl)propyl)triphenylphosphonium iodide (21955-58-8) → 1-[(1R,4S)-4-(4,4-Dimethoxy-1-methylene-butyl)-2,2-dimethyl-cyclobutyl]-4-(diphenyl-phosphinoyl)-3-methyl-6-(2-methyl-[1,3]dioxolan-2-yl)-hexan-3-ol (851779-77-6)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaOH

2.1: n-BuLi / tetrahydrofuran / -78 - 0 °C

2.2: 41 percent / tetrahydrofuran / -78 - 20 °C

With sodium hydroxide; n-butyllithium; In tetrahydrofuran; 2.2: Warren modification of Wittig reaction;

DOI:10.1016/j.tet.2005.02.018

upstream raw materials:

(1'R,4'S)-4-[4'-(4,4-dimethoxy-1-methylidenebutyl)-2',2'-dimethylcyclobutyl]butan-2-one

1-diphenylphosphinoyl-4-(2-methyl-[1,3]dioxolan-2-yl)-propane

5-iodo-2-pentanone

(3-(2-methyl-1,3-dioxolan-2-yl)propyl)triphenylphosphonium iodide