5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one

Base Information

Chemical Name:5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one
CAS No.:120551-46-4
Molecular Formula:C₂₁H₂₅N₃O₃
Molecular Weight:367.448
Hs Code.:

Synonyms:5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one

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Chemical Property of 5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one

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Technology Process of 5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one

There total 6 articles about 5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4053-44-5
5-(hydroxymethyl)-8-hydroxyquinoline

: 120551-46-4
5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) NaH / 1.) DMF, 45 min, 2.) DMF, 4 h

2: m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / Ambient temperature

3: 55 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h

4: 1.98 g / Ac₂O / 2.5 h / 50 °C

5: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

6: 245 mg / butan-1-ol / 20 h / Heating

7: 33 mg / H₂ / 5percent Pd/C / methanol / 0.58 h / 1292.9 Torr

With hydrogen; acetic anhydride; sodium hydride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium on activated charcoal; In methanol; dichloromethane; butan-1-ol;
DOI:10.1021/jm00392a006

Reference yield:

: 66546-38-1
8-(benzyloxy)carbostyril-5-carboxaldehyde

: 120551-46-4
5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

2: 245 mg / butan-1-ol / 20 h / Heating

3: 33 mg / H₂ / 5percent Pd/C / methanol / 0.58 h / 1292.9 Torr

With hydrogen; sodium hydride; dimethyl sulfoxide; palladium on activated charcoal; In methanol; butan-1-ol;
DOI:10.1021/jm00392a006

Reference yield:

: 108835-25-2
8-(benzyloxy)-5-(hydroxymethyl)quinoline

: 120551-46-4
5-{2-[2-(4-Amino-phenyl)-1,1-dimethyl-ethylamino]-1-hydroxy-ethyl}-8-hydroxy-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 4 h / Ambient temperature

2: 55 percent / pyridinium chlorochromate / CH₂Cl₂ / 1 h

3: 1.98 g / Ac₂O / 2.5 h / 50 °C

4: 1.) NaH, DMSO / 1.) THF, 15 min, 2.) THF, 15 min

5: 245 mg / butan-1-ol / 20 h / Heating

6: 33 mg / H₂ / 5percent Pd/C / methanol / 0.58 h / 1292.9 Torr

With hydrogen; acetic anhydride; sodium hydride; dimethyl sulfoxide; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; palladium on activated charcoal; In methanol; dichloromethane; butan-1-ol;
DOI:10.1021/jm00392a006