butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate

Base Information

Chemical Name:butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate
CAS No.:870773-52-7
Molecular Formula:C₂₄H₃₅FN₂O₅
Molecular Weight:450.551
Hs Code.:

Synonyms:butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate

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Chemical Property of butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate

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Technology Process of butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate

There total 10 articles about butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 690257-83-1
(3S)-1-[(2S,3S)-2-[(tert-butoxycarbonyl)amino]-3-(4-bromophenyl)-1-oxobutanyl]-3-fluoropyrrolidine

: 201230-82-2
carbon monoxide

: 71-36-3
butan-1-ol

: 870773-52-7
butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate

Guidance literature:: With triethylamine; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾;
DOI:10.1016/j.bmcl.2007.02.066

Reference yield:

: 690257-82-0
(2R,3S)-2-azido-3-(4-bromophenyl)butanoic acid

: 870773-52-7
butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate

Guidance literature:: Multi-step reaction with 4 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / DMF (N,N-dimethyl-formamide) / 12 h / 20 °C

2: triphenylphosphine / 1,4-dioxane; water / 12 h / 90 °C

3: sodium hydrogencarbonate / 1,4-dioxane; water / 12 h / 20 °C

4: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 24 h / 90 °C / 760.05 Torr

With sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; DMF (N,N-dimethyl-formamide); water;

Reference yield:

: 705292-65-5
(2S,3S)-2-Amino-3-(4-bromo-phenyl)-1-((S)-3-fluoro-pyrrolidin-1-yl)-butan-1-one

: 870773-52-7
butyl 4-{(1S,2S)-2-[(tert-butoxycarbonyl)amino]-3-[(3S)-3-fluoropyrrolidin-1-yl]-1-methyl-3-oxopropyl}benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 12 h / 20 °C

2: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 24 h / 90 °C / 760.05 Torr

With sodium hydrogencarbonate; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In 1,4-dioxane; water;