1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione
CAS No.:351523-11-0
Molecular Formula:C₂₇H₃₆N₂O₈
Molecular Weight:516.591
Hs Code.:

1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Synonyms:1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Chemical Property of 1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

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Technology Process of 1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

There total 6 articles about 1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 22423-26-3
O-2,2'-cyclo-5-methyluridine

: 351523-11-0
1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 3 steps

1: TsOH*H₂O / acetonitrile / 20 °C

2: KOH / ethanol / 20 °C

3: NaH / tetrahydrofuran / 20 °C

With potassium hydroxide; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; ethanol; acetonitrile;
DOI:10.1016/S0960-894X(01)00207-4

Reference yield:

: 100-39-0
benzyl bromide

: 351523-08-5
1-(3,5-O-di(tetrahydropyran-2-yl)-β-D-arabinofuranosyl)thymine

: 351523-11-0
1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 20 ℃;
DOI:10.1016/S0960-894X(01)00207-4

Reference yield:

: C₂₀H₃₀N₂O₇

: 351523-11-0
1-[(2R,3S,4R,5R)-3-Benzyloxy-4-(tetrahydro-pyran-2-yloxy)-5-(tetrahydro-pyran-2-yloxymethyl)-tetrahydro-furan-2-yl]-5-methyl-1H-pyrimidine-2,4-dione

Guidance literature:: Multi-step reaction with 2 steps

1: 420 mg / KOH / ethanol / 4 h / Heating

2: NaH / tetrahydrofuran / 16 h / 22 - 25 °C

With potassium hydroxide; sodium hydride; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmc.2007.01.049