tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate

Base Information

Chemical Name:tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate
CAS No.:1431944-12-5
Molecular Formula:C₁₈H₂₃Cl₂N₃O₃
Molecular Weight:400.305
Hs Code.:

Synonyms:tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate

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Chemical Property of tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate

Chemical Property:

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Technology Process of tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate

There total 4 articles about tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1431944-11-4
tert-butyl (2-{[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate

: 79-04-9
chloroacetyl chloride

: 1431944-12-5
tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 0.5h;

Reference yield:

: 154607-01-9
4-bromo-2-chlorobenzonitrile

: 1431944-12-5
tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium chloride / toluene / Reflux

2: ozone / methanol; dichloromethane / 0.17 h / -78 °C

3: sodium cyanoborohydride; acetic acid / methanol; dichloromethane / 3 h / 20 °C

4: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium cyanoborohydride; ozone; acetic acid; triethylamine; lithium chloride; In methanol; dichloromethane; toluene;

Reference yield:

: 1374357-72-8
2-chloro-4-(2-oxoethyl)benzonitrile

: 1431944-12-5
tert-butyl (2-{(chloroacetyl)[2-(3-chloro-4-cyanophenyl)ethyl]amino}ethyl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium cyanoborohydride; acetic acid / methanol; dichloromethane / 3 h / 20 °C

2: triethylamine / dichloromethane / 0.5 h / 0 - 20 °C

With sodium cyanoborohydride; acetic acid; triethylamine; In methanol; dichloromethane;