(S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester
CAS No.:869093-10-7
Molecular Formula:C₃₉H₄₅N₃O₉
Molecular Weight:699.801
Hs Code.:

Synonyms:(S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester

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Chemical Property of (S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester

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Technology Process of (S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester

There total 6 articles about (S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 852332-12-8
(1S,3R,5S)-3,5-Bis-((S)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarboxylic acid

: 7524-50-7
methyl (2S)-2-amino-3-phenylpropanoate hydrochloride

: 869093-10-7
(S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester

Guidance literature:: With triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; In methanol;
DOI:10.1002/chem.200500007

Reference yield:

: (1R,3S,5R)-5-(Imidazole-1-carbonyl)-cyclohexane-1,3-dicarboxylic acid

: 869093-10-7
(S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 38.16 g / dimethylsulfoxide; ethyl acetate

2: 45 percent / Et₃N; DMT-MM / methanol / 20 °C

3: 97 percent / H₂ / Pd/C / methanol; propan-2-ol; CH₂Cl₂ / 72 h

4: 54 percent / DMT-MM; Et₃N / methanol

With hydrogen; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol;
DOI:10.1002/chem.200500007

Reference yield:

: 852332-10-6
CHex(OBn)(COOH)2

: 869093-10-7
(S)-2-{[(3S,5R)-3,5-Bis-((R)-1-methoxycarbonyl-2-phenyl-ethylcarbamoyl)-cyclohexanecarbonyl]-amino}-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 45 percent / Et₃N; DMT-MM / methanol / 20 °C

2: 97 percent / H₂ / Pd/C / methanol; propan-2-ol; CH₂Cl₂ / 72 h

3: 54 percent / DMT-MM; Et₃N / methanol

With hydrogen; triethylamine; 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride; palladium on activated charcoal; In methanol; dichloromethane; isopropyl alcohol;
DOI:10.1002/chem.200500007