benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate

Base Information

Chemical Name:benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate
CAS No.:66365-74-0
Molecular Formula:C₂₉H₃₄N₂O₈
Molecular Weight:538.598
Hs Code.:

Synonyms:benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate

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Chemical Property of benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate

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Technology Process of benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate

There total 11 articles about benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 74839-17-1
t-butyl 5'-benzyloxycarbonyl-3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5-carboxylate

: 66365-74-0
benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate

Guidance literature:: With trifluoroacetic acid; at 20 ℃; for 1h;
DOI:10.1039/P19870000277

Reference yield:

: 60204-91-3
t-butyl 5-iodo-4-(2-methoxycarbonylethyl)-3-methylpyrrole-2-carboxylate

: 66365-74-0
benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / anhyd. sodium acetate,, H₂ / platinum oxide / ethanol / 4 h / 20 °C / 760 Torr

2: 76 percent / p-TsOH*H₂O / acetic acid / 3 h / 45 °C

3: 93 percent / trifluoroacetic acid / 1 h / 20 °C

With hydrogen; sodium acetate; toluene-4-sulfonic acid; trifluoroacetic acid; platinum(IV) oxide; In ethanol; acetic acid;
DOI:10.1039/P19870000277

Reference yield:

: 39265-95-7
methyl 3-acetyl-4-oxopentanoate

: 66365-74-0
benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) CCl₄, Mg / 1.) ethanol, reflux, 6 h; 2.) reflux, 3 h, 5 deg C

2: 16 percent

4: 76 percent / p-TsOH*H₂O / acetic acid / 3 h / 45 °C

5: 93 percent / trifluoroacetic acid / 1 h / 20 °C

With tetrachloromethane; toluene-4-sulfonic acid; magnesium; trifluoroacetic acid; In acetic acid;
DOI:10.1039/P19870000277