39265-95-7

Usage

Uses

Used in Organic Synthesis:
Methyl 3,3-diacetylpropanoate is used as an intermediate in organic synthesis for the production of various chemical compounds. Its role in this application is crucial for the synthesis of complex organic molecules, which can be further utilized in different industries.
Used in Research Applications:
Methyl 3,3-diacetylpropanoate is used as a research compound for studying its chemical properties and potential applications in various fields. It is often employed in academic and industrial research settings to explore its reactivity, stability, and interactions with other chemical entities.
Used in Specialized Applications:
Methyl 3,3-diacetylpropanoate is used in specialized applications where its unique chemical structure and properties are required. These applications may include the development of new materials, pharmaceuticals, or other advanced technologies that benefit from its specific characteristics.

InChI:InChI=1/C8H12O4/c1-5(9)7(6(2)10)4-8(11)12-3/h7H,4H2,1-3H3

Upstream product

• 15435-71-9 sodium acetoacetonate 
• 96-34-4 methyl chloroacetate 
• 96-32-2 bromoacetic acid methyl ester 
• 123-54-6 acetylacetone 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 6277-50-5 methyl 3-methylene-4-oxopentanoate 
• 31837-62-4 benzyl 4-<(methoxycarbonyl)methyl>-3,5-dimethylpyrrole-2-carboxylate 
• 992-36-9 dibenzyl 3,3'-bis(2-methoxycarbonylethyl)-4,4'-dimethyl-2,2'-pyrromethane-5,5'-dicarboxylate 
• 50622-64-5 benzyl 3-(2-methoxycarbonylethyl)-4-methoxycarbonylmethyl-5-methylpyrrole-2-carboxylate 
• 50622-67-8 5-acetoxymethyl-3-(2-methoxycarbonyl-ethyl)-4-methoxycarbonylmethyl-pyrrole-2-carboxylic acid benzyl ester 
• 74839-17-1 t-butyl 5'-benzyloxycarbonyl-3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5-carboxylate 
• 66365-74-0 benzyl 3,4'-bis(2-methoxycarbonylethyl)-3'-methoxycarbonylmethyl-4-methylpyrromethane-5'-carboxylate 
• 17484-82-1 benzyl 5-dimethylamido-3,4'-dimethyl-4,3'-bis(2'-methoxycarbonylethyl)-pyrromethane-5'-carboxylate 
• 130693-50-4 8-(2-chloroethyl)-1,4,6-triethyl-1',2,3,5,7,8'-hexamethyl-ac-biladiene dihydrobromide 
• 130693-51-5 1-(2'-chloroethyl)-4,6,8-triethyl-1',2,3,5,7,8'-hexamethyl-ac-biladiene dihydrobromide 
• 130693-48-0 4-(2'-chloroethyl)-1,6,8-triethyl-1,2,3,5,7,8'-hexamethyl-ac-biladiene dihydrobromide 
• 32710-89-7 (3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-acetic acid methyl ester 

Relevant academic research and scientific papers

Application of Rh-catalyzed cyclization for the construction of three consecutive chiral carbons in 4,9-dimethylspiro[4.4]nonane-2,7-dione

Asymmetric cyclization using Rh-complexes has been applied to the synthesis of 4,9-dimethylspiro[4.4]nonane-2,7-diones. The spiro[4.4]nonane skeleton bearing three consecutive chiral carbons could be stepwisely constructed from an identical starting material by the combination of a cationic Rh[(S)-BINAP]ClO4 and a neutral RhCl(PPh3)3. The relationship between the stereochemistry of the spirodiketones and the Rh-complex was also discussed. (C) 2000 Elsevier Science Ltd.

Enatio- and diastereoselective construction of 4,9-dimethylspiro[4.4]nonane-2,7-dione using Rh-catalyzed asymmetric cyclization

Asymmetric cyclization using Rh-complexes was applied to the synthesis of 4,9-dimethylspiro[4.4]nonane-2,7-diones. The spiro[4.4]nonane skeleton bearing a chiral quaternary carbon could be stepwisely constructed by using Rh-catalyzed cyclization twice. All diastereomers of the spirodiketone could be stereoselectively prepared from the identical starting material by the combination of a neutral Rh(PPh3)3Cl and a cationic Rh[BINAP]ClO4. The cyclization by the neutral Rh(PPh3)3Cl proceeded to give cis-3,4-disubstituted cyclopentanones, while that by the cationic Rh[BINAP]ClO4 proceeded to afford trans-3,4-disubstituted cyclopentanones. Four spirodiketones of six stereoisomers could be prepared in optically active form, and the relationship between the stereochemistry of the spirodiketones and the Rh-complex was discussed based on the plausible acyl-hydride Rh-complexes.

Application of Rh-catalyzed cyclization to the formation of a chiral quaternary carbon

Rh-Catalyzed cyclization was applied to the formation of a chiral quaternary carbon. It has become clear that the Rh-complex can discriminate between isopropenyl and 2-isopentenyl (or isopentyl) substituents, and the cyclization afforded 3,3,4-trisubstituted cyclopentanones with a chiral quaternary carbon in a stereoselective manner. The cyclization of 4-pentenals 6a, b by an achiral neutral Rh(PPh3)3Cl afforded 3,3,4-cis-trisubstituted cyclopentanones (±)-7a, b in 86-96%, and the cyclization by a cationic Rh[(R)-BINAP]ClO4 afforded 3,3,4-trans-trisubstituted cyelopentanones (-)-8a, b of 82-86% ee in 88-98% yields. The mechanism of stereoselection by Rh-complexes is also discussed.

Synthesis and Characterisation of the C30-De-ethylaetioporphyrin Present in Petroleum

The four de-ethyl analogues of the relatively ubiquitous and biogenetically significant petroporphyrin aetioporphyrin III (3a-d) have been synthesized utilising the ac-biladiene route.A reversed-phase HPLC method of separating a mixture of the four synthe

Synthetic and Biosynthetic Studies of Porphyrins. Part 8. Synthese of Hepta-, Hexa-, and penta-carboxylic Porphyrins Related to Urophorphin-I

The title porphyrins of interest as abnormal metabolits in porphyrins biosynthesis, have been synthesized by the Fischer, and b-oxobilane routes, and compared with the naturally derived materials.Enzymic experiments have shown that the conversion of uropo

Pyrrole Chemistry. An Improved Synthesis of Ethyl Pyrrole-2-carboxylate Esters from Diethyl Aminomalonate

Ethyl pyrrole-2-carboxylates, versatile precursors for the total synthesis of both synthetic model and naturally occurring tetrapyrroles and porphyrins, can be prepared in greatly improved yields by the addition of 1,3-diketones and preformed diethyl aminomalonate to boiling glacial acetic acid.The method is suitable for both small- and large-scale synthesis and has proved far more reliable than the original in situ dissolving zinc reduction of diethyl oximinomalonate discovered by Kleinspehn.Yields range from 60-70percent for the dominant product isomer from unsymmetrical diketones to 75-90percent for the single product derived from symmetrical diketones.Seventeen examples of alkyl-substituted ethyl pyrrole-2-carboxylates are provided.Improved procedures are given for the preparation of the required precursors.

Pyrazol-4-acetic acid compounds

Pyrazol-4-acetic acid compounds, such as substituted pyrazol-4-acetic acid, its esters, amides, nitriles and their pharamaceutically acceptable salts and method for the preparation of these compounds are disclosed. The novel compounds are useful analgesics, anti-inflammatory, and antipyretics.