(S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester

Base Information

• Chemical Name: (S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester
• CAS No.: 478182-51-3
• Molecular Formula: C₂₅H₂₆N₂O₆S
• Molecular Weight: 482.557

Synonyms:(S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester

Chemical Property of (S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester

There total 2 articles about (S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

methanol (67-56-1) + (S)-N-(N-(benzyloxycarbonyl)sulfamoyl)phenylalanine benzyl ester (478182-49-9) → (S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester (478182-51-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1021/jm020258v

Reference yield:

benzyl N-chlorosulfonylcarbamate (89979-13-5) → (S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester (478182-51-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 2 h / 20 °C

2: 69 percent / PPh₃; diisopropyl azodicarboxylate / CH₂Cl₂ / 1 h / 20 °C

With di-isopropyl azodicarboxylate; triethylamine; triphenylphosphine; In dichloromethane; 2: Mitsunobu reaction;

DOI:10.1021/jm020258v

Reference yield:

(S)-N-(N-(benzyloxycarbonyl)-N-methylsulfamoyl)phenylalanine benzyl ester (478182-51-3) → (S)-N-(N-methylsulfamoyl)phenylalanine

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h;

DOI:10.1021/jm020258v

upstream raw materials:

methanol

(S)-N-(N-(benzyloxycarbonyl)sulfamoyl)phenylalanine benzyl ester

benzyl N-chlorosulfonylcarbamate

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