ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate

Base Information

Chemical Name:ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate
CAS No.:767270-91-7
Molecular Formula:C₂₈H₂₉FN₆O₃
Molecular Weight:516.575
Hs Code.:

Synonyms:ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate

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Chemical Property of ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate

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Technology Process of ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate

There total 11 articles about ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₈H₂₉FN₆O₄

: 767270-91-7
ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate

Guidance literature:: With 5%-palladium/activated carbon; ammonium formate; acetic acid; at 120 ℃; Inert atmosphere;
DOI:10.1007/s13738-015-0743-4

Reference yield:

: 96-99-1
4-chloro-3-nitrobenzoate

: 767270-91-7
ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: water / 5 h / 80 °C

2.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 30 °C

3.1: triethylamine / dichloromethane / 5 h / 30 °C

4.1: zinc; ammonium chloride / water; tetrahydrofuran / 80 °C / Inert atmosphere

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran; N,N-dimethyl-formamide / 0.58 h / Cooling with ice

5.2: 30 °C

6.1: acetic acid / 120 °C

7.1: triethylamine; hydroxylamine hydrochloride / ethanol / 80 °C

8.1: acetic acid; 5%-palladium/activated carbon; ammonium formate / 120 °C / Inert atmosphere

With thionyl chloride; 5%-palladium/activated carbon; hydroxylamine hydrochloride; ammonium formate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1007/s13738-015-0743-4

Reference yield:

: 41263-74-5
4-(methylamino)-3-nitrobenzoic acid

: 767270-91-7
ethyl 3-(2-(((4-carbamimidoylphenyl)amino)methyl)-N-(3-fluorophenyl)-1-methyl-1H-benzo[d]imidazole-5-carboxamido)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / dichloromethane / 30 °C

2.1: triethylamine / dichloromethane / 5 h / 30 °C

3.1: zinc; ammonium chloride / water; tetrahydrofuran / 80 °C / Inert atmosphere

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran; N,N-dimethyl-formamide / 0.58 h / Cooling with ice

4.2: 30 °C

5.1: acetic acid / 120 °C

6.1: triethylamine; hydroxylamine hydrochloride / ethanol / 80 °C

7.1: acetic acid; 5%-palladium/activated carbon; ammonium formate / 120 °C / Inert atmosphere

With thionyl chloride; 5%-palladium/activated carbon; hydroxylamine hydrochloride; ammonium formate; ammonium chloride; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; N,N-dimethyl-formamide; zinc; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1007/s13738-015-0743-4