(R)-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>methanesulfonate

Base Information

• Chemical Name: (R)-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>methanesulfonate
• CAS No.: 171612-41-2
• Molecular Formula: C₁₈H₃₁O₉PS
• Molecular Weight: 454.478

Synonyms:(R)-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>methanesulfonate

Chemical Property of (R)-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>methanesulfonate

Chemical Property:

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Technology Process of (R)-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>methanesulfonate

There total 1 articles about (R)-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanesulfonyl chloride (124-63-0) + diethyl (R)-<4-(benzyloxymethoxymethyl)-5-hydroxy-2-oxapentane>phosphonate (171612-40-1) → (R)-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>methanesulfonate (171612-41-2)

Guidance literature:

With triethylamine; In dichloromethane; 0 deg C to RT;

DOI:10.1016/0040-4020(95)00557-O

Reference yield: 22.0%

Cytosine (71-30-7) + (R)-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>methanesulfonate (171612-41-2) → (R)-1-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>cytosine (171612-43-4) + [(R)-3-(4-Amino-pyrimidin-2-yloxy)-2-benzyloxymethoxymethyl-propoxymethyl]-phosphonic acid diethyl ester

Guidance literature:

With CsCO₃; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

DOI:10.1016/0040-4020(95)00557-O

upstream raw materials:

methanesulfonyl chloride

diethyl (R)-<4-(benzyloxymethoxymethyl)-5-hydroxy-2-oxapentane>phosphonate

Downstream raw materials:

(R)-1-<2'-(benzyloxymethoxymethyl)-3'-(diethylphosphonomethoxy)propyl>cytosine

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