N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide

Base Information

Chemical Name:N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide
CAS No.:71989-12-3
Molecular Formula:C₆₄H₉₅N₉O₁₃
Molecular Weight:1198.51
Hs Code.:

N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide

Synonyms:N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide

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Chemical Property of N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide

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Technology Process of N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide

There total 12 articles about N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61-90-5,21675-61-6,25248-98-0,70-45-1
L-leucine

: 71989-12-3
N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / 2N NaOH / H₂O; tetrahydrofuran

2: 74 percent / diisopropylethylamine, 1-hydroxybenzotriazole monohydrate, DCC / CH₂Cl₂ / 1.) 0 deg C, 0.5 h; 2.) room temperature 1.5 h.

3: 46 percent / NH₃ / methanol / 1.) 0 deg C; 2.) room temperature 5 days

4: 1.) H₂, 2.) HOBt (monohydrate), DCC / Pd-black / 1.) EtOH, 3 h; 2.) DMF, room temperature, 3h.

5: 1.) diethylamine, 2.) HOBt / 1.) DMF, 2 h, 2.) DMF, 3 h.

6: 1.) HNEt₂, 2.) DCC, HOBt / 1.) DMF, 2 h, room temperature; 2.) DMF, 2 h, room temperature.

7: 1.) NHEt₂; 2.) HOBt / 1.) DMF, 2 h, room temperature; 2.) DMF, 2 h, room temperature.

With sodium hydroxide; ammonia; hydrogen; benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; diethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo01289a016

Reference yield:

: 10512-93-3
Z-Val-ONp

: 71989-12-3
N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / 2N NaOH / H₂O; tetrahydrofuran

2: 74 percent / diisopropylethylamine, 1-hydroxybenzotriazole monohydrate, DCC / CH₂Cl₂ / 1.) 0 deg C, 0.5 h; 2.) room temperature 1.5 h.

3: 46 percent / NH₃ / methanol / 1.) 0 deg C; 2.) room temperature 5 days

4: 1.) H₂, 2.) HOBt (monohydrate), DCC / Pd-black / 1.) EtOH, 3 h; 2.) DMF, room temperature, 3h.

5: 1.) diethylamine, 2.) HOBt / 1.) DMF, 2 h, 2.) DMF, 3 h.

6: 1.) HNEt₂, 2.) DCC, HOBt / 1.) DMF, 2 h, room temperature; 2.) DMF, 2 h, room temperature.

7: 1.) NHEt₂; 2.) HOBt / 1.) DMF, 2 h, room temperature; 2.) DMF, 2 h, room temperature.

With sodium hydroxide; ammonia; hydrogen; benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; diethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jo01289a016

Reference yield:

: 17708-79-1
(S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanamido)-4-methylpentanoic acid

: 71989-12-3
N-<<(9-Fluorenylmethyl)oxy>carbonyl>-O-tert-butyl-L-tyrosyl-L-leucyl-L-asparaginyl-O-tert-butyl-L-seryl-L-valyl-L-leucyl-O-tert-butyl-L-threoninamide

Guidance literature:: Multi-step reaction with 6 steps

1: 74 percent / diisopropylethylamine, 1-hydroxybenzotriazole monohydrate, DCC / CH₂Cl₂ / 1.) 0 deg C, 0.5 h; 2.) room temperature 1.5 h.

2: 46 percent / NH₃ / methanol / 1.) 0 deg C; 2.) room temperature 5 days

3: 1.) H₂, 2.) HOBt (monohydrate), DCC / Pd-black / 1.) EtOH, 3 h; 2.) DMF, room temperature, 3h.

4: 1.) diethylamine, 2.) HOBt / 1.) DMF, 2 h, 2.) DMF, 3 h.

5: 1.) HNEt₂, 2.) DCC, HOBt / 1.) DMF, 2 h, room temperature; 2.) DMF, 2 h, room temperature.

6: 1.) NHEt₂; 2.) HOBt / 1.) DMF, 2 h, room temperature; 2.) DMF, 2 h, room temperature.

With ammonia; hydrogen; benzotriazol-1-ol; 1-hydroxybenzotriazol-hydrate; diethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; palladium; In methanol; dichloromethane;
DOI:10.1021/jo01289a016