6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

Base Information

Chemical Name:6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide
CAS No.:1418024-13-1
Molecular Formula:C₂₂H₁₅Cl₂N₃O₂
Molecular Weight:424.286
Hs Code.:

Synonyms:6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

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Chemical Property of 6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

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Technology Process of 6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

There total 8 articles about 6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1402345-30-5
4-chloro-N-methoxy-N-methyl-2-phenylamino-benzamide

: 1418024-13-1
6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

2.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

4.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

5.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.25 h / 760.05 Torr / Inert atmosphere

6.2: 1.5 h / 760.05 Torr / Inert atmosphere

With platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1402345-31-6
1-(4-chloro-2-phenylamino-phenyl)propan-1-one

: 1418024-13-1
6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

1.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

2.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

3.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

4.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.25 h / 760.05 Torr / Inert atmosphere

5.2: 1.5 h / 760.05 Torr / Inert atmosphere

With platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 936-08-3
2-bromo-4-chlorobenzoic acid

: 1418024-13-1
6-chloro-N-(7-chloro-4-oxo-1-phenyl-1,4-dihydro-quinolin-3-ylmethyl)nicotinamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: copper; copper(I) oxide; potassium carbonate / 2-ethoxy-ethanol / 0.08 h / 20 °C / 760.05 Torr / Inert atmosphere

1.2: 48 h / 135 °C / 760.05 Torr / Inert atmosphere

1.3: 20 °C / 760.05 Torr

2.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C / 760.05 Torr / Inert atmosphere

3.1: tetrahydrofuran / 2 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

4.1: oxalyl dichloride / tetrahydrofuran / 1.5 h / 0 - 20 °C / 760.05 Torr / Inert atmosphere

4.2: 2 h / 115 °C / 760.05 Torr / Inert atmosphere

5.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 1 h / 115 °C / 760.05 Torr / Inert atmosphere

6.1: sodium azide / N,N-dimethyl-formamide / 20 °C / 760.05 Torr / Inert atmosphere

7.1: platinum(IV) oxide; hydrogen / ethyl acetate / 5 h / 20 °C / 760.05 Torr / Inert atmosphere

8.1: N-ethyl-N,N-diisopropylamine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate / dichloromethane / 0.25 h / 760.05 Torr / Inert atmosphere

8.2: 1.5 h / 760.05 Torr / Inert atmosphere

With copper(I) oxide; platinum(IV) oxide; N-Bromosuccinimide; sodium azide; oxalyl dichloride; 2,2'-azobis(isobutyronitrile); hydrogen; copper; potassium carbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 2-ethoxy-ethanol; tetrachloromethane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;