(2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane

Base Information

• Chemical Name: (2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane
• CAS No.: 928050-49-1
• Molecular Formula: C₁₈H₂₆O₃
• Molecular Weight: 290.403
• Mol file: 928050-49-1.mol

Synonyms:(2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane

Chemical Property of (2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane

There total 2 articles about (2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

benzyl bromide (100-39-0) + (1S)-1-<(2R)-1,4-dioxaspiro<4,5>dec-2-yl>propanol (257860-45-0) → (2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane (928050-49-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.11.171

Reference yield:

(R)-2,3-cyclohexylideneglyceraldehyde (78008-36-3) → (2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane (928050-49-1)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / 0 °C

2: 83 percent / NaH / tetrahydrofuran

With sodium hydride; In tetrahydrofuran; diethyl ether;

DOI:10.1016/j.tetlet.2006.11.171

Reference yield: 80.0%

(2R)-2-[(1S)-1-(benzyloxy)propyl]-1,4-dioxaspiro[4.5]-decane (928050-49-1) → (2R,3S)-3-(benzyloxy)pentane-1,2-diol (99838-62-7)

Guidance literature:

With water; trifluoroacetic acid; at 0 ℃; for 2h;

DOI:10.1016/j.tet.2009.06.060

upstream raw materials:

benzyl bromide

(1S)-1-<(2R)-1,4-dioxaspiro<4,5>dec-2-yl>propanol

(R)-2,3-cyclohexylideneglyceraldehyde

Downstream raw materials:

(S)-(-)-2-Benzyloxybutyraldehyde

C₁₂H₁₄Br₂O

C₁₂H₁₄O

C₂₁H₂₈O₄