Technology Process of (4S,5R)-N-(2,3-dimethylbenzoyl)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone
There total 7 articles about (4S,5R)-N-(2,3-dimethylbenzoyl)-4-fluoromethyl-5-<4-(methylsulphonyl)phenyl>-2-oxazolidinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: K2CO3 / H2O / 1 h / Ambient temperature
2: t-BuOK / ethanol / 3 h / Heating
3: 81 percent / H2O2 / H2O / 20 h / 45 °C
4: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
5: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
With
N-(2-chloro-1,1,2-trifluoroethyl)diethylamine; n-butyllithium; potassium tert-butylate; dihydrogen peroxide; potassium carbonate;
In
ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: t-BuOK / ethanol / 3 h / Heating
2: 81 percent / H2O2 / H2O / 20 h / 45 °C
3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
With
N-(2-chloro-1,1,2-trifluoroethyl)diethylamine; n-butyllithium; potassium tert-butylate; dihydrogen peroxide;
In
ethanol; water; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: K2CO3 / H2O / 1 h / Ambient temperature
2: EtONa / ethanol
3: 40 percent / (2-chloro-1,1,2-trifluoroethyl)diethylamine / acetonitrile / 1.) room temp., 1 h, 2.) reflux, 3 h
4: 1.) BuLi / 1.) THF, 0 deg C, 30 min, 2.) 0 deg C, 30 min; room temp., 1 h
With
N-(2-chloro-1,1,2-trifluoroethyl)diethylamine; n-butyllithium; sodium ethanolate; potassium carbonate;
In
ethanol; water; acetonitrile;