((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde

Base Information

• Chemical Name: ((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde
• CAS No.: 252575-67-0
• Molecular Formula: C₁₆H₂₁NO₃
• Molecular Weight: 275.348
• Mol file: 252575-67-0.mol

Synonyms:((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde

Chemical Property of ((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde

There total 3 articles about ((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

2R,5S,6R-2-ethyl-4,5-dimethyl-2-(2-propenyl)-6-phenyl-morpholin-3-one (207223-26-5) → ((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde (252575-67-0)

Guidance literature:

With sodium periodate; osmium(VIII) oxide; In tetrahydrofuran; toluene; at 20 ℃;

DOI:10.1016/S0957-4166(99)00343-2

Reference yield:

ephedrine hydrochloride (50-98-6) → ((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde (252575-67-0)

Guidance literature:

Multi-step reaction with 3 steps

1: Et₃N; DMAP / CH₂Cl₂

2: TiCl₄ / CH₂Cl₂ / -40 °C

3: 85 percent / aq. OsO₄; NaIO₄ / tetrahydrofuran; toluene / 20 °C

With dmap; sodium periodate; osmium(VIII) oxide; titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane; toluene; 1: cyclocondensation / 2: allylation / 3: oxidative cleavage;

DOI:10.1016/S0957-4166(99)00343-2

Reference yield:

2S,5S,6R-2-ethyl-4,5-dimethyl-2-hydroxy-6-phenyl-morpholin-3-one (207223-20-9) → ((2R,5S,6R)-2-Ethyl-4,5-dimethyl-3-oxo-6-phenyl-morpholin-2-yl)-acetaldehyde (252575-67-0)

Guidance literature:

Multi-step reaction with 2 steps

1: TiCl₄ / CH₂Cl₂ / -40 °C

2: 85 percent / aq. OsO₄; NaIO₄ / tetrahydrofuran; toluene / 20 °C

With sodium periodate; osmium(VIII) oxide; titanium tetrachloride; In tetrahydrofuran; dichloromethane; toluene; 1: allylation / 2: oxidative cleavage;

DOI:10.1016/S0957-4166(99)00343-2

upstream raw materials:

2R,5S,6R-2-ethyl-4,5-dimethyl-2-(2-propenyl)-6-phenyl-morpholin-3-one

ephedrine hydrochloride

2S,5S,6R-2-ethyl-4,5-dimethyl-2-hydroxy-6-phenyl-morpholin-3-one

Downstream raw materials:

(2R,5S,6R)-2-Ethyl-2-(2-hydroxy-ethyl)-4,5-dimethyl-6-phenyl-morpholin-3-one