tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate

Base Information

• Chemical Name: tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate
• CAS No.: 1346137-01-6
• Molecular Formula: C₁₅H₂₃N₃O₅S
• Molecular Weight: 357.431
• Mol file: 1346137-01-6.mol

Synonyms:tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate

Chemical Property of tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate

There total 1 articles about tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.9%

N-BOC-1,2-diaminoethane (57260-73-8) + p-acetylaminobenzenesulfonyl chloride (121-60-8) → tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate (1346137-01-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1016/j.tet.2019.01.002

Reference yield: 99.0%

tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate (1346137-01-6) → 4-amino-N-(2-aminoethyl)benzenesulfonamide dihydrochloride

Guidance literature:

With hydrogenchloride; Reflux; Inert atmosphere;

DOI:10.1021/ja204488p

Reference yield:

tert-butyl-2-(4acetamidophenyl sulfonamido)ethylcarbamate (1346137-01-6) → N-Boc-N'-(4-aminophenylsulfonyl)-ethylenediamine (902775-91-1)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 3h; Reflux;

DOI:10.1021/acs.jmedchem.8b00315

upstream raw materials:

N-BOC-1,2-diaminoethane

p-acetylaminobenzenesulfonyl chloride

Downstream raw materials:

N-Boc-N'-(4-aminophenylsulfonyl)-ethylenediamine