902775-91-1Relevant academic research and scientific papers
Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4
Li, Cong,Deng, Xiaobing,Zhang, Weilin,Xie, Xiaowen,Conrad, Marcus,Liu, Ying,Angeli, José Pedro Friedmann,Lai, Luhua
, p. 266 - 275 (2019/01/15)
Glutathione peroxidase 4 (GPX4) is essential for cell membrane repair, inflammation suppression, and ferroptosis inhibition. GPX4 upregulation provides unique drug discovery opportunities for inflammation and ferroptosis-related diseases. However, rationa
Phospholipid hydroperoxide glutathione peroxidase activating agents and application
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Paragraph 0090; 0091, (2018/02/04)
The invention discloses a type of phospholipid hydroperoxide glutathione peroxidase (GPX4) activating agents and application. A structural formula I of the activating agents is as shown in the specification, wherein X refers to a straight chain or branche
Immobilization of an artificial imine reductase within silica nanoparticles improves its performance
Hestericová, Martina,Correro, M. Rita,Lenz, Markus,Corvini, Philippe F.-X.,Shahgaldian, Patrick,Ward, Thomas R.
supporting information, p. 9462 - 9465 (2016/07/29)
Silica nanoparticles equipped with an artificial imine reductase display remarkable activity towards cyclic imine- and NAD+ reduction. The method, based on immobilization and protection of streptavidin on silica nanoparticles, shields the bioti
Artificial transfer hydrogenases based on the biotin-(strept)avidin technology: Fine tuning the selectivity by saturation mutagenesis of the host protein
Letondor, Christophe,Pordea, Anca,Humbert, Nicolas,Ivanova, Anita,Mazurek, Sylwester,Novic, Marjana,Ward, Thomas R.
, p. 8320 - 8328 (2007/10/03)
Incorporation of biotinylated racemic three-legged d6-piano stool complexes in streptavidin yields enantioselective transfer hydrogenation artificial metalloenzymes for the reduction of ketones. Having identified the most promising organometallic catalyst precursors in the presence of wild-type streptavidin, fine-tuning of the selectivity is achieved by saturation mutagenesis at position S112. This choice for the genetic optimization site is suggested by docking studies which reveal that this position lies closest to the biotinylated metal upon incorporation into streptavidin. For aromatic ketones, the reaction proceeds smoothly to afford the corresponding enantioenriched alcohols in up to 97% ee (R) or 70% (S). On the basis of these results, we suggest that the enantioselection is mostly dictated by CH/π interactions between the substrate and the η6-bound arene. However, these enantiodiscriminating interactions can be outweighed in the presence of cationic residues at position S112 to afford the opposite enantiomers of the product.
