(2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

Base Information

Chemical Name:(2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine
CAS No.:1632122-17-8
Molecular Formula:C₂₄H₃₁NO₂Si
Molecular Weight:393.601
Hs Code.:

Synonyms:(2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

Suppliers and Price of (2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

There total 3 articles about (2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₅H₃₀N₂O₂Si

: 1632122-18-9
(2S,3aR,4S,6S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

: 1632122-17-8
(2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

Guidance literature:: With silica gel; lithium triethylborohydride; In tetrahydrofuran; at 0 ℃; for 0.5h; Overall yield = 13 mg;
DOI:10.1055/s-0033-1340107

Reference yield:

: 1431853-29-0
(2S,3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

: 1632122-17-8
(2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

Guidance literature:: Multi-step reaction with 3 steps

1.1: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -60 °C

2.2: 0.5 h / -60 °C

3.1: lithium triethylborohydride; silica gel / tetrahydrofuran / 0.5 h / 0 °C

With n-butyllithium; silica gel; diisobutylaluminium hydride; lithium triethylborohydride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1055/s-0033-1340107

Reference yield:

: 1431853-30-3
(2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

: 1632122-17-8
(2S,3aR,4S,6R,8aR,8bS)-4-{[dimethyl(phenyl)silyl]methyl}-6-methyl-2-phenylhexahydro-3aH-[1,3]dioxolo[4,5-a]pyrrolizine

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.25 h / -60 °C

1.2: 0.5 h / -60 °C

2.1: lithium triethylborohydride; silica gel / tetrahydrofuran / 0.5 h / 0 °C

With silica gel; lithium triethylborohydride; lithium diisopropyl amide; In tetrahydrofuran;
DOI:10.1055/s-0033-1340107