(2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

Base Information

Chemical Name:(2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles
CAS No.:1431853-30-3
Molecular Formula:C₂₄H₂₈N₂O₂Si
Molecular Weight:404.584
Hs Code.:

Synonyms:(2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

Suppliers and Price of (2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

There total 2 articles about (2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7677-24-9
trimethylsilyl cyanide

: 1431853-29-0
(2S,3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one

: 1431853-30-3
(2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

: 1431853-31-4
(2S,3aR,4S,6S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

Guidance literature:: (2S,3aR,4S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-[1,3]dioxolo[4,5-a]pyrrolizin-6-one; With n-butyllithium; diisobutylaluminium hydride; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere;

trimethylsilyl cyanide; In tetrahydrofuran; hexane; at 0 ℃; for 0.333333h; Overall yield = 97 %; Overall yield = 0.135 g; Inert atmosphere;
DOI:10.1021/jo400386f

Reference yield:

: 1027340-35-7
(5S,6R,7S,7aR)-6,7-dihydroxy-5-((dimethyl(phenyl)silyl)methyl)-hexahydropyrrolizin-3-one

: 1125-88-8
benzaldehyde dimethyl acetal

: 1431853-30-3
(2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

: 1431853-31-4
(2S,3aR,4S,6S,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene-4-sulfonic acid / dichloromethane / 16 h / 20 °C / Inert atmosphere

2.1: diisobutylaluminium hydride; n-butyllithium / tetrahydrofuran; hexane / 0 - 20 °C / Inert atmosphere

2.2: 0.33 h / 0 °C / Inert atmosphere

With n-butyllithium; diisobutylaluminium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; hexane; dichloromethane;
DOI:10.1021/jo400386f

Reference yield:

: 1431853-30-3
(2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles

: 74-88-4
methyl iodide

: C₂₅H₃₀N₂O₂Si

Guidance literature:: (2S,3aR,4S,6R,8aR,8bS)-4-((dimethyl(phenyl)silyl)methyl)-2-phenylhexahydro-4H-[1,3]dioxolo[4,5-a]pyrrolizine-6-carbonitriles; With lithium diisopropyl amide; In tetrahydrofuran; at -60 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; at -60 ℃; for 0.5h;
DOI:10.1055/s-0033-1340107