(1R)-1-(4,5-diphenyloxazol-2-yl)methylamino-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Base Information

Chemical Name:(1R)-1-(4,5-diphenyloxazol-2-yl)methylamino-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene
CAS No.:187993-41-5
Molecular Formula:C₄₂H₄₂N₂O₂Si
Molecular Weight:634.893
Hs Code.:

Synonyms:(1R)-1-(4,5-diphenyloxazol-2-yl)methylamino-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

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Chemical Property of (1R)-1-(4,5-diphenyloxazol-2-yl)methylamino-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

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Technology Process of (1R)-1-(4,5-diphenyloxazol-2-yl)methylamino-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

There total 2 articles about (1R)-1-(4,5-diphenyloxazol-2-yl)methylamino-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5-(tert-butyl-diphenyl-silanyloxy)-1,2,3,4-tetrahydro-naphthalen-1-ylamine

: 81819-14-9
(4,5-diphenyloxazol-2-yl)methyl bromide

: 187993-41-5
(1R)-1-(4,5-diphenyloxazol-2-yl)methylamino-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.04.042

Reference yield:

: 187993-40-4
(1R)-1-azido-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

: 81819-14-9
(4,5-diphenyloxazol-2-yl)methyl bromide

: 187993-41-5
(1R)-1-(4,5-diphenyloxazol-2-yl)methylamino-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene

Guidance literature:: (1R)-1-azido-5-t-butyldiphenylsilyloxy-1,2,3,4-tetrahydronaphthalene; With hydrogen; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; for 2h;

(4,5-diphenyloxazol-2-yl)methyl bromide; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 2h;