N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide

Base Information

• Chemical Name: N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide
• CAS No.: 1443221-44-0
• Molecular Formula: C₂₂H₂₁N₇O₂S
• Molecular Weight: 447.52
• Mol file: 1443221-44-0.mol

Synonyms:N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide

Chemical Property of N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide

There total 3 articles about N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methoxybenzoyl)thiourea (1443221-61-1) + 2-amino-4-dimethylamino-6-chloromethyl-1,3,5-triazine (21320-37-6) → N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide (1443221-44-0)

Guidance literature:

In methanol; at 70 ℃; for 24h;

DOI:10.1016/j.ejmech.2013.03.020

Reference yield:

benzonitrile (100-47-0) → N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide (1443221-44-0)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminum (III) chloride / 0 - 30 °C

2: toluene / 3 h / -5 - 20 °C

3: methanol / 24 h / 70 °C

With aluminum (III) chloride; In methanol; toluene;

DOI:10.1016/j.ejmech.2013.03.020

Reference yield:

N,N-diethylbenzamidine (50458-37-2) → N-(5-(4-amino-6-(dimethylamino)-1,3,5-triazin-2-yl)-4-phenylthiazol-2-yl)-4-methoxybenzamide (1443221-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene / 3 h / -5 - 20 °C

2: methanol / 24 h / 70 °C

In methanol; toluene;

DOI:10.1016/j.ejmech.2013.03.020

upstream raw materials:

N,N-diethylbenzamidine

benzonitrile

1-[1-diethylamino-1-phenylmeth-(E)-ylidene]-3-(4-methoxybenzoyl)thiourea

2-amino-4-dimethylamino-6-chloromethyl-1,3,5-triazine