(4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

Base Information

Chemical Name:(4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one
CAS No.:210635-04-4
Molecular Formula:C₃₁H₄₂N₂O₅
Molecular Weight:522.685
Hs Code.:

Synonyms:(4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

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Chemical Property of (4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

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Technology Process of (4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

There total 3 articles about (4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 210635-00-0
Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester

: 210635-04-4
(4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

Guidance literature:: With sodium hydroxide; In methanol; for 1h; Ambient temperature;
DOI:10.1021/jo980533e

Reference yield:

: 153223-21-3
XK₂₃₄

: 210635-04-4
(4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1.3 g / diisopropylethylamine / CH₂Cl₂ / 8 h / Heating

2: 0.9 g / PPh₃, DEAD / tetrahydrofuran / 20 h / Ambient temperature

3: 0.4 g / 1N aq. NaOH / methanol / 1 h / Ambient temperature

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jm9803626

Reference yield:

: 152929-98-1
(4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one

: 210635-04-4
(4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 0.9 g / PPh₃, DEAD / tetrahydrofuran / 20 h / Ambient temperature

2: 0.4 g / 1N aq. NaOH / methanol / 1 h / Ambient temperature

With sodium hydroxide; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol;
DOI:10.1021/jm9803626