Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester

Base Information

• Chemical Name: Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester
• CAS No.: 210635-00-0
• Molecular Formula: C₃₃H₄₃ClN₂O₆
• Molecular Weight: 599.167
• Mol file: 210635-00-0.mol

Synonyms:

Chemical Property of Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester

There total 3 articles about Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

XK234 (153223-21-3) → Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester (210635-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.3 g / diisopropylethylamine / CH₂Cl₂ / 8 h / Heating

2: 0.9 g / PPh₃, DEAD / tetrahydrofuran / 20 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm9803626

Reference yield:

chloroacetyl chloride (79-04-9) + (4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one (152929-98-1) → Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester (210635-00-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 20h; Ambient temperature;

DOI:10.1021/jm9803626

Reference yield:

chloroacetic acid (79-11-8) + (4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one (152929-98-1) → Chloro-acetic acid (S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl ester (210635-00-0)

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; for 20h; Ambient temperature;

DOI:10.1021/jo980533e

upstream raw materials:

chloroacetic acid

(4R,5S,6S,7R)-hexahydro-5-(2-methoxyethoxymethoxy)-6-hydroxy-1,3-bis--4,7-bis--2H-1,3-diazepin-2-one

chloroacetyl chloride

XK₂₃₄

Downstream raw materials:

(4R,5S,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-hydroxy-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

(4R,5R,6R)-4-Benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-6-phenethyl-tetrahydro-pyrimidin-2-one

(4R,5S,6S)-4-Benzyl-1,3-bis-cyclopropylmethyl-6-((S)-1-fluoro-2-phenyl-ethyl)-5-(2-methoxy-ethoxymethoxy)-tetrahydro-pyrimidin-2-one

Imidazole-1-carbothioic acid O-{(S)-1-[(4R,5S,6R)-6-benzyl-1,3-bis-cyclopropylmethyl-5-(2-methoxy-ethoxymethoxy)-2-oxo-hexahydro-pyrimidin-4-yl]-2-phenyl-ethyl} ester