Technology Process of Tert-butyl 3-chloro-6-(2-(dibenzylamino)ethoxy)indazole-1-carboxylate
There total 7 articles about Tert-butyl 3-chloro-6-(2-(dibenzylamino)ethoxy)indazole-1-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
diamide; triphenylphosphine;
In
tetrahydrofuran;
at 20 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium nitrite; tetrafluoroboric acid / water / 0.67 h / 0 °C
1.2: 0.5 h / 50 - 130 °C
2.1: sodium hydroxide; water / ethanol / 1 h / 20 °C
2.2: pH ~ 7
3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C
4.1: N-chloro-succinimide; potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
5.1: triethylamine / dmap / tetrahydrofuran / 20 °C
6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
7.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C
With
1H-imidazole; N-chloro-succinimide; tetrafluoroboric acid; diamide; potassium tert-butylate; tetrabutyl ammonium fluoride; water; triethylamine; triphenylphosphine; sodium hydroxide; sodium nitrite;
dmap;
In
tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-chloro-succinimide; potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere
2: triethylamine / dmap / tetrahydrofuran / 20 °C
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C
4: triphenylphosphine; diamide / tetrahydrofuran / 20 °C
With
N-chloro-succinimide; diamide; potassium tert-butylate; tetrabutyl ammonium fluoride; triethylamine; triphenylphosphine;
dmap;
In
tetrahydrofuran;
