(rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide

Base Information

Chemical Name:(rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide
CAS No.:1469979-66-5
Molecular Formula:C₁₈H₁₆F₄N₂O
Molecular Weight:352.331
Hs Code.:

Synonyms:(rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide

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Chemical Property of (rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide

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Technology Process of (rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide

There total 5 articles about (rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 7.0%

: (rac)-4-(3-fluoro-4-trifluoromethyl-phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-ylamine

: 79-03-8
propionyl chloride

: 1469979-66-5
(rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Inert atmosphere;

Reference yield:

: 204339-72-0
3-fluoro-4-trifluoromethyl-benzaldehyde

: 1469979-66-5
(rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / methanol / 14 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / toluene / 230 °C / Inert atmosphere

3.1: sodium hydrogencarbonate; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh); tert.-butylhydroperoxide / dichloromethane / 48 h / 20 °C / Inert atmosphere

4.1: ammonium acetate / methanol; ethanol / 1 h / 20 °C / Inert atmosphere

4.2: 0.75 h / 20 °C / Inert atmosphere; Reflux

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

With tert.-butylhydroperoxide; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh); ammonium acetate; sodium hydrogencarbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; 2.1: |Diels-Alder Cycloaddition;

Reference yield:

: 1445218-26-7
4-[3-fluoro-4-(trifluoromethyl)phenyl]-6,7-dihydro-5H-cyclopenta[c]pyridine

: 1469979-66-5
(rac)-N-(4-(3-fluoro-4-(trifluoromethyl)phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-7-yl)propionamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh); tert.-butylhydroperoxide / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: ammonium acetate / methanol; ethanol / 1 h / 20 °C / Inert atmosphere

2.2: 0.75 h / 20 °C / Inert atmosphere; Reflux

3.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / Inert atmosphere

With tert.-butylhydroperoxide; tetrakis(μ-caprolactamato)dirhodium(Rh-Rh); ammonium acetate; sodium hydrogencarbonate; N-ethyl-N,N-diisopropylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;