10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid

Base Information

Chemical Name:10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid
CAS No.:135227-41-7
Molecular Formula:C₂₇H₃₆N₂O₇
Molecular Weight:500.592
Hs Code.:

Synonyms:10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid

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Chemical Property of 10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid

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Technology Process of 10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid

There total 6 articles about 10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 108-30-5
succinic acid anhydride

: 135227-40-6
N-(tert-Butoxycarbonyl)-N',2(S)-bis(benzyloxy)-1,4-butanediamine

: 135227-41-7
10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid

Guidance literature:: With pyridine; at 80 ℃; for 2h;
DOI:10.1021/jo00019a017

Reference yield:

: 79722-21-7
tert-butyl N-(benzyloxy)carbamate

: 135227-41-7
10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, room temperature, 15 min, 2.) 0 deg C to room temperature, several h

2: 1.) NaH / 1.) DMF, room temperature, 1 h, 2.) 70-80 deg C, 18 h

3: 85 percent / K₂CO₃, H₂O / methanol / 1.5 h / Heating

4: 3.4 g / trifluoroacetic acid / CH₂Cl₂ / 0.25 h / Ambient temperature

5: 3.06 g / tetrahydrofuran / 17 h / 0 deg C to r.t.

6: 65 percent / pyridine / 2 h / 80 °C

With pyridine; water; sodium hydride; potassium carbonate; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1021/jo00019a017

Reference yield:

: 135227-39-3
N',2(S)-Bis(benzyloxy)-1,4-butanediamine

: 135227-41-7
10-(tert-Butoxycarbonyl)-5,8(S)-bis(benzyloxy)-4-oxo-5,10-diazadecanoic Acid

Guidance literature:: Multi-step reaction with 2 steps

1: 3.06 g / tetrahydrofuran / 17 h / 0 deg C to r.t.

2: 65 percent / pyridine / 2 h / 80 °C

With pyridine; In tetrahydrofuran;
DOI:10.1021/jo00019a017