2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid

Base Information

Chemical Name:2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid
CAS No.:900174-22-3
Molecular Formula:C₂₉H₃₅N₃O₈
Molecular Weight:553.612
Hs Code.:

Synonyms:2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid

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Chemical Property of 2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid

Chemical Property:

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Technology Process of 2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid

There total 1 articles about 2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 745020-22-8
imidodicarbonic acid 2-(6-amino-1-isoquinolinyl)-1,3-bis(1,1-dimethylethyl)ester

: 122775-35-3
3,4-Dimethoxyphenylboronic acid

: 298-12-4
Glyoxilic acid

: 900174-22-3
2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid

Guidance literature:: In methanol; toluene; at 20 - 50 ℃; for 3h;

Reference yield:

: 900174-71-2
(R)-methyl (4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)carbamate hydrochloride

: 900174-22-3
2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid

: 1520082-85-2
C₄₄H₅₅N₅O₁₁S

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml400453z

Reference yield:

: 900174-71-2
(R)-methyl (4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)carbamate hydrochloride

: 900174-22-3
2-(1-bis(1,1-dimethylethoxycarbonyl)aminoisoquinolin-6-ylamino)-2-(3,4-dimethoxyphenyl)acetic acid

: 1520082-63-6
methyl (3-((R)-1-((R)-2-((1-aminoisoquinolin-6-yl)amino)-2-(3,4-dimethoxyphenyl)acetyl)pyrrolidin-2-yl)-4-(isopropylsulfonyl)phenyl)carbamate trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / 20 °C / Inert atmosphere

2.1: hydrogenchloride / ethyl acetate; water; 1,4-dioxane / 4 h / 20 °C / Inert atmosphere

2.2: 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; ethyl acetate;
DOI:10.1021/ml400453z