4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester

Base Information

Chemical Name:4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester
CAS No.:1306720-03-5
Molecular Formula:C₂₁H₂₂ClN₃O₅S
Molecular Weight:463.942
Hs Code.:

Synonyms:4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester

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Chemical Property of 4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester

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Technology Process of 4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester

There total 6 articles about 4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.0%

: 75-44-5
phosgene

: 17849-38-6
2-Chlorobenzyl alcohol

: 1306720-32-0
N-[4-(piperazine-1-sulfonyl)phenyl]acrylamide

: 1306720-03-5
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester

Guidance literature:: phosgene; 2-Chlorobenzyl alcohol; In tetrahydrofuran; toluene; at 20 ℃; for 3h; Inert atmosphere;

N-[4-(piperazine-1-sulfonyl)phenyl]acrylamide; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1306720-00-2
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid tert-butyl ester

: 1306720-03-5
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm201310y

Reference yield:

: 98-74-8
4-Nitrobenzenesulfonyl chloride

: 1306720-03-5
4-(4-acryloylaminobenzenesulfonyl)piperazine-1-carboxylic acid 2-chlorobenzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 20 °C / Inert atmosphere

2: iron; ammonium chloride / ethanol; water / 2 h / 80 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 18 h

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

5: N-ethyl-N,N-diisopropylamine / tetrahydrofuran

With iron; ammonium chloride; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm201310y